Maazị A -----Lymphoma B-cell dị iche iche (DLBCL)

Maazị A, onye si India, onye dị afọ iri isii na isii, malitere njem ahụike ya na Eprel afọ 2018. Mgbe e mechara nyocha biopsy nke oke ibu n'aka ekpe ya, ma mee nyocha PET-CT zuru oke nke ahụ ya dum, a chọpụtara Diffuse Large B-Cell Lymphoma (DLBCL). Nke a gosiri mmalite nke usoro ọgwụgwọ siri ike nke ebumnuche ya bụ ịlụso ọrịa ahụ ọgụ.

N'ịbụ onye na-eme usoro ọgwụgwọ R-EPOCH chemotherapy nke isii na mbụ, Maazị A mechara gbanwee gaa na usoro ọgwụgwọ R-GDP atọ, wee soro usoro ọgwụgwọ abụọ ọzọ nke otu ahụ. Usoro ọgwụgwọ ọgwụgwọ a siri ike malitere site na Eprel 2018 ruo Ọktoba 2019, oge a na-eji ntachi obi na ntachi obi mara n'agbanyeghị ihe isi ike.

N'agbanyeghị ọgwụgwọ siri ike ahụ, ihe ndọghachi azụ pụtara n'oge nyochaghachi PET-CT nke Ọktoba 2019, na-ekpughe nsogbu metabolic ọhụrụ na mpaghara akwara aka nri na femur aka nri. N'enweghị nkụda mmụọ, Maazị A, n'agbanyeghị ihe ọmụma nke ọkwa BIOOCUS Medical Group dịka ụlọ ọrụ CAR-T kachasị elu n'ụwa niile, chọrọ ahụmịhe ya.

Nọvemba 2019 bụ oge mgbanwe dị mkpa ka Maazị A malitere usoro ọgwụgwọ ọhụrụ n'okpuru nlekọta nke ndị otu ahụike anyị. Nnyocha zuru oke gosiri na CD19 dị nro na CD22 dị mma nke ukwuu, nke na-egosi nnukwu ọrụ etuto ahụ fọdụrụnụ. N'ihi nchọpụta ndị a, e kpebiri ịga n'ihu na ọgwụgwọ mkpụrụ ndụ CD19+CD22 CAR-T, usoro kachasị ọhụrụ nke dị njikere iji lụso ọrịa kansa na-aga n'ihu ọgụ.

Mgbe agbanyechara ọgwụ ahụ, Maazị A nwetara ọrịa Cytokine Release Syndrome (CRS) nke nwere ike ịchịkwa, wee gbakee ngwa ngwa. Ka ọ na-erule Jenụwarị 2020, a tọhapụrụ ya, ihe ndị a chọpụtara na nyocha PET-CT kachasị ọhụrụ gosiri mmụba nke etuto ahụ na mbelata dị ukwuu na ọrụ metabolic.

Njem Maazị A na-eje ozi dị ka ihe ngosi olileanya, na-egosi ike mgbanwe nke ọgwụgwọ dị elu n'ihe gbasara ọrịa kansa. Ka ọ na-amalite usoro nlekọta ndị ọrịa na-aga ụlọ ọgwụ ogologo oge, ihe a na-elekwasị anya bụ ịnọgide na-enwe ike ọhụrụ na ichebe onwe ya pụọ ​​​​na nlọghachi nke ọrịa ahụ.