Mr. A ----Te Lymphoma Pūtau-B Nui e horapa ana (DLBCL)

Nō Īnia a Mr. A, he tangata hihiri, 66 tau te pakeke, ā, i tīmata tana haerenga hauora i te Paenga-whāwhā 2018. Whai muri i te tango i te koiora o te puranga i tōna ringa maui, me te matawai PET-CT whānui o te tinana katoa, i puta te tātaritanga o te Diffuse Large B-Cell Lymphoma (DLBCL). Koinei te tīmatanga o tētahi tikanga maimoatanga pakari e aro ana ki te whawhai ki te mate.

I te tīmatanga, e ono ngā huringa o te maimoatanga rongoā matepukupuku R-EPOCH i mua, ā, i muri mai ka neke atu a Mr. A ki ngā huringa e toru o te maimoatanga R-GDP, ā, i muri mai ka rua atu ngā huringa o taua maimoatanga. Ko tēnei maimoatanga rongoā matepukupuku kaha i ahu mai i Āperira 2018 ki Oketopa 2019, he wā i tohuhia e te manawanui me te manawanui i roto i ngā raruraru.

Ahakoa te uaua o te maimoatanga, i puta ake he raruraru i te wā o te aromatawai anō i te PET-CT i te marama o Oketopa 2019, i kitea ai he hapa hou i roto i te pūnaha io i te rohe o te calcaneus matau me te femur matau. Kāore i mataku, i rapu a Mr. A i tōna tohungatanga ki te hiranga o BIOOCUS Medical Group hei pokapū CAR-T matua o te ao.

I te marama o Noema 2019, he wā tino nui tēnei i tīmata ai a Mr. A i tētahi wāhanga hou o te maimoatanga i raro i te manaaki a tā mātou tīma hauora. I kitea i roto i ngā whakamātautau whānui he iti te pai o te CD19 me te kaha o te CD22, he tohu tēnei mō te kaha o te mahi pūtau toenga. I runga i ēnei kitenga, i whakatauhia kia haere tonu me te rongoā pūtau CD19+CD22 CAR-T, he huarahi hou kua rite ki te whakatau i te mate pukupuku pumau.

Whai muri i te werohanga, ka pāngia a Mr. A e te mate tukunga cytokine (CRS) taumata 2, ā, ka tere tonu tana ora. Nō te marama o Hānuere 2020, ka tukuna ia ki te hōhipera, me te harikoa hoki nā ngā hua pai o te matawai PET-CT hou e whakaatu ana i te hokinga mai o te pukupuku me te hekenga nui o te mahi pākia.

Ko te haerenga a Mr. A he tohu o te tumanako, e whakaatu ana i te kaha whakarerekē o ngā wawaotanga hauora matatau i roto i te ao o te mate pukupuku. I a ia e tīmata ana i tētahi kaupapa tirotiro ā-waho mō te wā roa, ko te arotahi tonu ko te pupuri i te kaha hou me te tiaki i a ia mai i te hokinga mai o te mate.