Mnu. A -----Diffuse Large B-cell Lymphoma (DLBCL)

UMnu. A, ongowaseIndiya, umntu ophilileyo oneminyaka engama-66 ubudala, waqalisa uhambo lwakhe lwezonyango ngo-Epreli 2018. Emva kokuhlolwa kwe-biopsy ye-mass engalweni yakhe yasekhohlo, kunye ne-PET-CT scan epheleleyo yomzimba wonke, kwafunyaniswa ukuba une-Diffuse Large B-Cell Lymphoma (DLBCL). Oku kwaphawula ukuqaliswa kwenkqubo yonyango oluqatha olujolise ekulweni nesi sifo.

Ekuqaleni, uMnu. A watshintshela kwimijikelo emithandathu iyonke ye-R-EPOCH chemotherapy regimen, waza kamva watshintshela kwimijikelo emithathu ye-R-GDP regimen, walandelwa yimijikelo emibini eyongezelelweyo efanayo. Le regimen ye-chemotherapy enzulu yaqala ngo-Epreli 2018 ukuya ku-Okthobha 2019, ixesha elibonakala ngokunyamezela nokuqina xa ujongene nobunzima.

Nangona unyango olunzima, kwavela ingxaki ngexesha lovavanyo lwe-PET-CT ngo-Okthobha 2019, nto leyo eyatyhila ukungahambi kakuhle kwe-metabolic kwindawo ye-calcaneus yasekunene kunye ne-femur yasekunene ekude. Engatyhafiswanga, uMnu. A, enolwazi lokwahlulwa kwe-BIOOCUS Medical Group njengeziko eliphambili le-CAR-T kwihlabathi liphela, wafuna ulwazi lwayo.

UNovemba ka-2019 waphawula utshintsho olukhulu njengoko uMnu. A wayeqalisa inqanaba elitsha lonyango phantsi kokhathalelo lweqela lethu lezonyango. Uvavanyo olupheleleyo lwabonisa ukuba i-CD19 yayine-dim-positive kunye ne-CD22 enamandla kakhulu, nto leyo ebonisa ukuba kukho i-relief tumor activity ephezulu. Ngenxa yezi ziphumo, kwagqitywa ekubeni kuqhutyekwe nonyango lweeseli ze-CD19+CD22 CAR-T, indlela entsha elungele ukujongana nesifo somhlaza esiqhubekayo.

Emva kokufakwa kwesi sifo, uMnu. A wafumana i-degree 2 Cytokine Release Syndrome (CRS) elawulekayo, waza wachacha ngokukhawuleza emva koko. NgoJanuwari 2020, wakhululwa, evuselelwe ziziphumo ezithembisayo ezivela kwi-PET-CT scan yamva nje ebonisa ukwehla kwethumba kunye nokwehla okuphawulekayo komsebenzi we-metabolic.

Uhambo lukaMnu. A lusebenza njengokukhanya kwethemba, lugxininisa amandla okuguqula amanqanaba onyango aphambili kwicandelo le-oncology. Njengoko eqalisa inkqubo yokulandelela ixesha elide yezigulane ezingalaliswanga, ingqwalasela isasele ekulondolozeni amandla amatsha kunye nokukhusela ekuvukeni kwesi sifo.