I-Myasthenia gravis-02

Ibali likaLi Ming loNyango lweMyasthenia Gravis

ULi Ming, utitshala oneminyaka engama-35 ubudala, waqala ukuba neempawu ze-myasthenia gravis (MG) kwiminyaka emithathu eyadlulayo. Ekuqaleni, waphawula ukuba amehlo akhe awile kwaye kunzima ukuthetha, kodwa iimpawu zaqhubeka kancinci kancinci zaya kubuthathaka bemisipha ngokubanzi, nto leyo eyenza ukuba nemisebenzi yemihla ngemihla ibe nzima. Nangona wayefumana unyango olwahlukeneyo, kuquka ii-steroids kunye ne-immunosuppressants, iimpawu zakhe azizange zilawuleke.

Ngentshayelelo yomhlobo, uLi Ming wafika kwiBIOOCUS Medical Group ukuze athathe inxaxheba kuvavanyo lweklinikhi lweCAR-T. Iqela leengcali lenze uvavanyo oluneenkcukacha lweempawu zakhe laza lamlungiselela unyango lweCAR-T.

Inkqubo Yonyango:

1. Isigaba Sokulungiselela: Ngaphambi konyango, uLi Ming wavavanywa impilo yakhe ngokupheleleyo. Oogqirha bahlula iiseli ze-T emzimbeni wakhe baza baziguqula ngokwemfuza kwilebhu ukuze ziveze ii-chimeric antigen receptors (CAR) ezijolise kwii-antigen ezithile ezinxulumene ne-myasthenia gravis.

2. Ukwandiswa kweeSeli: Iiseli ze-CAR-T eziguquliweyo zandiswa kwilebhu ukuqinisekisa inani elaneleyo lonyango.

3. Unyango lweKhemotherapy oluQhelekileyo: Ngaphambi kokuba afakwe iiseli zeCAR-T, uLi Ming wenze irejimeni yekhemotherapy yeveki yonke ukunciphisa inani lee-lymphocytes ezikhoyo emzimbeni wakhe, nto leyo eyadala imeko-bume engcono yokuba iiseli zeCAR-T zisebenze ngokufanelekileyo.

4. Ukufakwa kweCell ye-CAR-T: Emva kokugqiba unyango lwe-chemotherapy, uLi Ming wangeniswa esibhedlele ukuze afumane ukufakwa kweCell ye-CAR-T. Le nkqubo yenziwa phantsi kweliso elibukhali ukuthintela iziphumo ebezingalindelekanga.

Iziphumo Zonyango:

1. Impendulo yexesha elifutshane: Kwiveki yokuqala emva kokufakwa kwe-infusion, uLi Ming wafumana umkhuhlane omncinci kunye nokudinwa, iimpendulo eziqhelekileyo zexesha elifutshane kunyango lweeseli zeCAR-T. Emva kweeveki ezimbini, i-ptosis yakhe kunye nobunzima bokuthetha kwaphucuka kakhulu, kwaye amandla akhe aqala ukubuya.

2. Uphuculo lwexesha eliphakathi: Emva kweenyanga ezimbini, iimpawu zikaLi Ming zazinciphile kakhulu. Wakwazi ukuqhubeka nemisebenzi yokufundisa eqhelekileyo, ukusebenza kakuhle kwakhe emsebenzini kwaphucuka, kwaye umgangatho wobomi bakhe wabonisa uphuculo olukhulu.

3. Iziphumo Zexesha Elide: Emva kweenyanga ezintathu emva konyango, uLi Ming wayengasaxhomekekanga kumayeza angaphambili. Uvavanyo olulandelayo lubonise ukuba inkqubo yakhe yomzimba yokuzikhusela yayikwimeko entle, kungekho ziphumo zimbi zibonakalayo.

Ngonyango lweeseli zeCAR-T, i-myasthenia gravis kaLi Ming yalawulwa kakhulu. "Ndibulela kakhulu unyango lweCAR-T kunye neqela lezonyango elizinikeleyo ngemizamo yabo," utshilo uLi Ming elila, exhawula isandla sikagqirha xa ephuma esibhedlele.