I-Myasthenia gravis-02

Indaba Yokwelashwa Kwe-Myasthenia Gravis KaLi Ming

ULi Ming, uthisha oneminyaka engu-35 ubudala, waqala ukuzwa izimpawu ze-myasthenia gravis (MG) eminyakeni emithathu edlule. Ekuqaleni, waphawula ukuthi amajwabu amehlo athambile kanye nobunzima bokukhuluma, kodwa izimpawu zaqhubeka kancane kancane zaba ubuthakathaka bemisipha obujwayelekile, okwenza ngisho nemisebenzi yansuku zonke ibe nzima. Naphezu kokwelashwa okuhlukahlukene, okuhlanganisa ama-steroids kanye nemithi yokucindezela amasosha omzimba, izimpawu zakhe azizange zilawulwe.

Ngesethulo somngane, uLi Ming wafika eBIOOCUS Medical Group ukuzohlanganyela ocwaningweni lwezokwelapha lwe-CAR-T. Ithimba lochwepheshe lenze ukuhlolwa okuningiliziwe kwezimpawu zakhe futhi lamlungiselela ukwelashwa kwe-CAR-T.

Inqubo Yokwelapha:

1. Isigaba Sokulungiselela: Ngaphambi kokwelashwa, uLi Ming wahlolwa impilo yakhe yonke. Odokotela bahlukanisa amaseli e-T emzimbeni wakhe futhi bawashintsha ngofuzo elabhorethri ukuze aveze ama-receptor e-chimeric antigen (CAR) aqondise kuma-antigen athile ahlobene ne-myasthenia gravis.

2. Ukwandiswa Kwamaseli: Amaseli e-CAR-T aguquliwe anwetshwa elabhorethri ukuqinisekisa inani elanele lokwelashwa.

3. Ukwelashwa Nge-Chemotherapy Ngaphambi Kokwelashwa: Ngaphambi kokufakwa kweseli le-CAR-T, uLi Ming wenziwa isimiso se-chemotherapy esathatha isonto lonke ukuze anciphise inani lama-lymphocyte akhona emzimbeni wakhe, okwakha indawo engcono yokuthi amaseli e-CAR-T asebenze kahle.

4. Ukufakwa Kweseli le-CAR-T: Ngemva kokuqeda ukwelashwa ngamakhemikhali, uLi Ming walaliswa esibhedlela ukuze athole ukufakwa kweseli le-CAR-T. Le nqubo yenziwa ngaphansi kokuqapha okuqinile ukuvimbela imiphumela emibi engaba khona.

Imiphumela Yokwelashwa:

1. Impendulo Yesikhashana: Ngesonto lokuqala ngemva kokufakwa, uLi Ming wabhekana nomkhuhlane omncane kanye nokukhathala, ukusabela okuvamile kwesikhashana ekwelashweni kwamaseli e-CAR-T. Ngemva kwamasonto amabili, i-ptosis yakhe kanye nobunzima bokukhuluma kwathuthuka kakhulu, futhi amandla akhe aqala ukubuya.

2. Ukuthuthuka Kwamaphakathi Nesikhathi: Ezinyangeni ezimbili kamuva, izimpawu zikaLi Ming zase zinciphile kakhulu. Wakwazi ukuqhubeka nemisebenzi yokufundisa evamile, ukusebenza kahle kwakhe emsebenzini kwathuthuka, futhi ikhwalithi yempilo yakhe yabonisa ukuthuthuka okukhulu.

3. Imiphumela Yesikhathi Eside: Ngemva kwezinyanga ezintathu elashwe, uLi Ming wayengasathembeli emithini yangaphambilini. Ukuhlolwa okulandelayo kubonise ukuthi amasosha akhe omzimba asesimweni esihle, kungekho miphumela emibi emibi ebonwe.

Ngokwelashwa ngamaseli e-CAR-T, i-myasthenia gravis kaLi Ming yalawulwa kakhulu. "Ngibonga kakhulu ukwelashwa kwe-CAR-T kanye nethimba lezokwelapha elizinikele ngemizamo yabo," kusho uLi Ming ekhala, exhawula udokotela lapho ephuma esibhedlela.