I-Myasthenia gravis-01

Indaba Yokwelashwa Kwe-Myasthenia Gravis KaZhang Wei

UZhang Wei, unjiniyela wesofthiwe oneminyaka engu-32 ubudala, waqala ukuzwa izimpawu ze-myasthenia gravis (MG) eminyakeni emibili edlule. Ekuqaleni, wayene-ptosis (izinkophe ezigobile) kanye nokungaboni kahle, kodwa izimpawu zakhe zaba zimbi kakhulu ngokuhamba kwesikhathi, okwaholela ebuthakathakeni bemisipha obujwayelekile obathinta kakhulu umsebenzi wakhe kanye nokuphila kwakhe kwansuku zonke. Naphezu kokwelashwa okuhlukahlukene, okuhlanganisa imithi ye-anticholinesterase, imithi yokucindezela amasosha omzimba, kanye ne-immunoglobulin efakwa emthanjeni, izimpawu zakhe zaqhubeka futhi zazivame ukuvela.

Njengoba izindlela zokwelapha zendabuko zingasebenzi, odokotela basikisela ukuthi uZhang Wei azame indlela entsha yokwelapha: ukwelashwa ngamaseli e-CAR-T. Lokhu kwelashwa okusha kusebenzisa ubunjiniyela bezakhi zofuzo ukuguqula amaseli e-T esiguli, okuwenza akwazi ukuqondisa nokususa amaseli angajwayelekile ahlobene nalesi sifo.

Ngemva kokuhlolwa okuphelele, uZhang Wei wabhekwa njengofanele ukwelashwa. Odokotela baqale bahlukanisa amaseli e-T emzimbeni wakhe futhi bawashintsha izakhi zofuzo futhi bawandisa elabhorethri. UZhang Wei wabe esethola ukwelashwa ngamakhemikhali okwelapha ukuze kuncishiswe inani lama-lymphocyte akhona emzimbeni wakhe, elungiselela ukwethulwa kwamaseli e-CAR-T. Ekugcineni, amaseli e-CAR-T aguquliwe aphinde afakwa emzimbeni kaZhang Wei.

Ngesikhathi sokuqala kokwelashwa, uZhang Wei wakhathala isikhashana, kodwa ngemva kwamasonto amabili, izimpawu zakhe zaqala ukuthuthuka kakhulu. I-ptosis kanye nombono ofiphele kwancipha kakhulu, futhi amandla akhe abuya kancane kancane. Ngemva kwenyanga, ukusebenza kahle kwakhe emsebenzini kwathuthuka, futhi wakwazi ukuqhubeka nemisebenzi evamile yansuku zonke. Ngemva kwezinyanga ezintathu elashwe, izimpawu zikaZhang Wei zase zicishe zanyamalala ngokuphelele, futhi wayengasadingi imithi yangaphambilini. Ukuhlolwa okulandelayo kwabonisa ukuthi amasosha akhe omzimba asesimweni esihle, engenamiphumela emibi noma izimpawu zokubuya kwesifo.

Ngokwelashwa ngamaseli e-CAR-T, i-myasthenia gravis kaZhang Wei yalawulwa kakhulu, yathuthukisa kakhulu ikhwalithi yempilo yakhe kanye nekhono lakhe lokusebenza. Lokhu kwelashwa kunikeza ithemba elisha ezigulini eziningi ezine-myasthenia gravis.