Te mate pāwera-01

Te Kōrero Maimoatanga mō te Myasthenia Gravis a Zhang Wei

I tīmata a Zhang Wei, he kaihanga pūmanawa 32-tau te pakeke, ki te pāngia e ngā tohu o te myasthenia gravis (MG) i ngā tau e rua ki muri. I te tīmatanga, he ptosis (he kamo e piko ana) me te tirohanga pōuriuri, engari i kino haere ana tohu i roto i te wā, ā, ka ngoikore haere ngā uaua whānui i tino pā ki tana mahi me tana oranga o ia rā. Ahakoa te whai i ngā maimoatanga maha, tae atu ki ngā rongoā anticholinesterase, ngā immunosuppressants, me te immunoglobulin intravenous, i mau tonu ana tohu, ā, i maha tonu te puta mai.

I te korenga o ngā rongoā tuku iho i whai hua, ka kī atu ngā tākuta kia whakamātau a Zhang Wei i tētahi tikanga rongoā hou: te rongoā pūtau CAR-T. Ka whakamahia e tēnei rongoā auaha te hangarau ira hei whakarerekē i ngā pūtau-T o te tūroro, kia taea ai e rātou te arotahi me te whakakore i ngā pūtau rerekē e pā ana ki te mate.

I muri i te aromatawai hōhonu, i kitea a Zhang Wei he tika mō te maimoatanga. I wehea tuatahitia e ngā tākuta ngā pūtau-T mai i tōna tinana, ā, i whakarerekētia ngā ira, ā, i whakawhānuihia i roto i te taiwhanga. Kātahi ka tukuna ki a Zhang Wei te rongoā chemotherapy hei whakaiti i te maha o ngā lymphocytes kei roto i tōna tinana, hei whakarite mō te whakaurunga mai o ngā pūtau CAR-T. Hei whakamutunga, ka whakahokia ngā pūtau CAR-T kua whakarerekētia ki roto i te tinana o Zhang Wei.

I te wā tuatahi o te maimoatanga, i pāngia a Zhang Wei e te ngenge poto, engari i muri i ngā wiki e rua, ka tīmata te tino pai haere o ana tohu. I tino heke te ptosis me te tirohanga pōuri, ā, ka hoki mārire tōna kaha. Kotahi te marama i muri mai, ka pai ake tana mahi, ā, ka taea e ia te hoki anō ki ngā mahi o ia rā. E toru ngā marama i muri i te maimoatanga, kua tata ngaro katoa ngā tohu o Zhang Wei, ā, kāore ia i hiahia ki ngā rongoā o mua. I whakaatuhia e ngā whakamātautau whai muri kei te pai te āhua o tana pūnaha ārai mate, kāore he pānga kino kino, he tohu rānei o te hokinga mai o te mate.

Mā te rongoā pūtau CAR-T, i tino whakahaeretia te myasthenia gravis o Zhang Wei, ā, i tino whakarei ake i tōna kounga o te oranga me tōna kaha ki te mahi. He tumanako hou tēnei mō te tini o ngā tūroro myasthenia gravis.