Myasthenia gravis-01

Nkhani ya Chithandizo cha Myasthenia Gravis ya Zhang Wei

Zhang Wei, mainjiniya wa mapulogalamu wazaka 32, anayamba kuona zizindikiro za myasthenia gravis (MG) zaka ziwiri zapitazo. Poyamba, anali ndi ptosis (zikope zopindika) komanso kusawona bwino, koma zizindikiro zake zinakula kwambiri pakapita nthawi, zomwe zinapangitsa kuti minofu ikhale yofooka kwambiri zomwe zinakhudza kwambiri ntchito yake ndi moyo wake watsiku ndi tsiku. Ngakhale kuti ankalandira chithandizo chamankhwala osiyanasiyana, kuphatikizapo mankhwala oletsa cholinesterase, mankhwala oletsa chitetezo chamthupi, ndi immunoglobulin m'mitsempha, zizindikiro zake zinapitirira ndipo nthawi zambiri zimabwereranso.

Popeza njira zochiritsira zachikhalidwe sizinagwire ntchito, madokotala adalangiza Zhang Wei kuti ayesere njira yatsopano yochiritsira: chithandizo cha maselo a CAR-T. Chithandizo chatsopanochi chimagwiritsa ntchito uinjiniya wa majini kuti asinthe maselo a T a wodwalayo, zomwe zimawathandiza kuti azitha kulunjika ndikuchotsa maselo osayenera okhudzana ndi matendawa.

Pambuyo powunika bwino, Zhang Wei adawonedwa kuti ndi woyenera kulandira chithandizochi. Madokotala adatenga maselo a T m'thupi lake ndikuwasintha majini ndikuwonjezera mu labotale. Kenako Zhang Wei adapatsidwa chithandizo cha chemotherapy kuti achepetse kuchuluka kwa ma lymphocyte omwe analipo m'thupi lake, kukonzekera kulowetsedwa kwa maselo a CAR-T. Pomaliza, maselo a CAR-T osinthidwawo adabwezeretsedwanso m'thupi la Zhang Wei.

Poyamba kulandira chithandizo, Zhang Wei anatopa kwakanthawi, koma patatha milungu iwiri, zizindikiro zake zinayamba kusintha kwambiri. Matenda a ptosis ndi kusawona bwino zinachepa kwambiri, ndipo mphamvu zake zinabwerera pang'onopang'ono. Patatha mwezi umodzi, kugwira ntchito bwino kunakula, ndipo anayambanso kuchita zinthu za tsiku ndi tsiku. Patatha miyezi itatu atatha kulandira chithandizo, zizindikiro za Zhang Wei zinali zitatha pang'ono, ndipo sankafunikanso mankhwala omwe adamupatsa kale. Kufufuza kotsatira kunasonyeza kuti chitetezo chake cha mthupi chinali bwino, popanda zotsatirapo zoyipa kapena zizindikiro zobwereranso kwa matenda.

Kudzera mu chithandizo cha maselo a CAR-T, matenda a myasthenia gravis a Zhang Wei adawongoleredwa kwambiri, zomwe zidamuthandiza kwambiri kukhala ndi moyo wabwino komanso luso lake logwira ntchito. Chithandizochi chimapereka chiyembekezo chatsopano kwa odwala ambiri omwe ali ndi matenda a myasthenia gravis.