Myasthenia gravis-01

Inkuru y'ubuvuzi bwa Zhang Wei bwa Myasthenia Gravis

Zhang Wei, injeniyeri w’imyaka 32, yatangiye kugira ibimenyetso bya myasthenia gravis (MG) mu myaka ibiri ishize. Mbere na mbere, yari afite ptosis (amaso ye yananutse) kandi atabona neza, ariko ibimenyetso bye byarushijeho kwiyongera uko igihe cyagiye gihita, bituma imitsi ye icika intege cyane, ibyo bikaba byaramugizeho ingaruka zikomeye ku kazi ke no ku buzima bwe bwa buri munsi. Nubwo yavurwaga mu buryo butandukanye, harimo imiti igabanya kolinesterase, imiti igabanya ubudahangarwa bw’umubiri, na immunoglobulin yo mu mitsi, ibimenyetso bye byarakomeje kandi byagarukaga kenshi.

Kubera ko uburyo gakondo bwo kuvura butari bufite icyo butanga, abaganga basabye Zhang Wei kugerageza uburyo bushya bwo kuvura: ubuvuzi bwa CAR-T cell. Ubu buryo bushya bwo kuvura bukoresha ikoranabuhanga rya genetiki kugira ngo buhindure uturemangingo twa T tw’umurwayi, butuma abasha kwibasira no gukuraho uturemangingo tudasanzwe dufitanye isano n’iyi ndwara.

Nyuma yo gusuzuma neza, Zhang Wei yafashwe nk'ukwiriye kuvurwa. Abaganga babanje gutandukanya uturemangingo twa T mu mubiri we maze bahindura imiterere y'uturemangingo maze batwongerera muri laboratwari. Hanyuma Zhang Wei yafashwe imiti ivura indwara kugira ngo agabanye umubare w'uturemangingo twa lymphocytes twari turi mu mubiri we, bitegura ko uturemangingo twa CAR-T twashyizwemo. Amaherezo, uturemangingo twa CAR-T twahinduwe twongeye gushyirwa mu mubiri wa Zhang Wei.

Mu gihe cy’itangira ry’ubuvuzi, Zhang Wei yagize umunaniro w’igihe gito, ariko nyuma y’ibyumweru bibiri, ibimenyetso bye byatangiye kumera neza cyane. Indwara yo kutabona neza no kutabona neza byagabanutse cyane, kandi imbaraga ze zaragarutse buhoro buhoro. Nyuma y’ukwezi kumwe, imikorere ye mu kazi yarushijeho kuba myiza, kandi yashoboraga kongera gukora imirimo isanzwe ya buri munsi. Amezi atatu nyuma yo kuvurwa, ibimenyetso bya Zhang Wei byari hafi gucika burundu, kandi ntiyari agikeneye imiti yabanje. Isuzuma ryakurikiyeho ryagaragaje ko ubudahangarwa bw’umubiri bwe bwari bumeze neza, nta ngaruka mbi zikomeye cyangwa ibimenyetso byo kugaruka kw’indwara.

Binyuze mu buvuzi bwa selile za CAR-T, indwara ya myasthenia gravis ya Zhang Wei yagenzuwe cyane, yongera cyane ubuzima bwe n'ubushobozi bwe bwo gukora. Ubu buvuzi butanga icyizere gishya ku barwayi benshi ba myasthenia gravis.