Myasthenia gravis-01

Labarin Maganin Myasthenia Gravis na Zhang Wei

Zhang Wei, injiniyan software mai shekaru 32, ya fara fuskantar alamun myasthenia gravis (MG) shekaru biyu da suka gabata. Da farko, yana da ptosis (faɗuwar ido) da kuma rashin gani sosai, amma alamominsa sun tsananta akan lokaci, wanda ya haifar da raunin tsoka gaba ɗaya wanda ya shafi aikinsa da rayuwarsa ta yau da kullun. Duk da shan magunguna daban-daban, ciki har da magungunan anticholinesterase, immunosuppressants, da immunoglobulin na jijiyoyi, alamunsa sun ci gaba kuma suna sake faruwa akai-akai.

Ganin cewa magungunan gargajiya sun gaza, likitoci sun ba da shawarar cewa Zhang Wei ya gwada sabuwar hanyar magani: maganin ƙwayoyin CAR-T. Wannan sabuwar hanyar magani tana amfani da injiniyan kwayoyin halitta don gyara ƙwayoyin T na majiyyaci, wanda ke ba su damar kai hari da kuma kawar da ƙwayoyin halitta marasa kyau da ke da alaƙa da cutar.

Bayan an yi cikakken bincike, an ga Zhang Wei ya dace da wannan magani. Likitoci sun fara ware ƙwayoyin T daga jikinsa kuma suka gyara su ta hanyar kwayoyin halitta sannan suka faɗaɗa su a dakin gwaje-gwaje. Daga nan sai Zhang Wei ya yi amfani da maganin chemotherapy don rage yawan ƙwayoyin lymphocytes da ke jikinsa, yana shirin shigar da ƙwayoyin CAR-T. A ƙarshe, an sake haɗa ƙwayoyin CAR-T da aka gyara cikin jikin Zhang Wei.

A lokacin farko na jiyya, Zhang Wei ya ɗan gaji na ɗan lokaci, amma bayan makonni biyu, alamun cutar sun fara inganta sosai. Ptosis da rashin gani sun ragu sosai, kuma ƙarfinsa ya dawo a hankali. Wata ɗaya bayan haka, ingancin aikinsa ya inganta, kuma ya iya ci gaba da ayyukan yau da kullun. Watanni uku bayan magani, alamun cutar Zhang Wei sun kusan ɓace gaba ɗaya, kuma ba ya buƙatar magungunan da suka gabata. Gwaje-gwajen da aka yi a baya sun nuna cewa garkuwar jikinsa tana cikin kyakkyawan yanayi, ba tare da wata mummunar illa ko alamun sake dawowar cutar ba.

Ta hanyar maganin ƙwayoyin cuta na CAR-T, an shawo kan cutar myasthenia gravis ta Zhang Wei sosai, wanda hakan ya ƙara masa inganci a rayuwarsa da kuma iya aikinsa. Wannan maganin yana ba da sabuwar fata ga yawancin marasa lafiya da ke fama da myasthenia gravis.