ʻO ka Myasthenia gravis-01

Ka Moʻolelo Lapaʻau no ka Myasthenia Gravis a Zhang Wei

Ua hoʻomaka ʻo Zhang Wei, he ʻenekinia polokalamu 32 makahiki, e ʻike i nā hōʻailona o ka myasthenia gravis (MG) i ʻelua mau makahiki i hala. I ka wā mua, ua loaʻa iā ia ka ptosis (nā maka e hāʻule ana) a me ka ʻike pohihihi, akā ua ʻoi aku ka ʻino o kāna mau hōʻailona i ka hala ʻana o ka manawa, e alakaʻi ana i ka nāwaliwali o nā ʻiʻo ākea i hoʻopilikia nui i kāna hana a me ke ola o kēlā me kēia lā. ʻOiai ke hana ʻia nei nā ʻano lāʻau like ʻole, me nā lāʻau anticholinesterase, nā immunosuppressants, a me ka immunoglobulin intravenous, ua mau kāna mau hōʻailona a hoʻi pinepine mai.

Me ka hōʻike ʻana o nā lāʻau lapaʻau kuʻuna i ka hopena ʻole, ua ʻōlelo aku nā kauka iā Zhang Wei e hoʻāʻo i kahi ʻano lapaʻau hou: ka lāʻau lapaʻau CAR-T cell. Hoʻohana kēia lāʻau lapaʻau hou i ka ʻenekinia genetic e hoʻololi i nā cell T ponoʻī o ka mea maʻi, e hiki ai iā lākou ke kuhikuhi a hoʻopau i nā cell ʻano ʻē e pili ana i ka maʻi.

Ma hope o ka loiloi piha ʻana, ua manaʻo ʻia ʻo Zhang Wei he kūpono no ka lāʻau lapaʻau. Ua hoʻokaʻawale mua nā kauka i nā pūnaewele T mai kona kino a hoʻololi i ke ʻano genetic a hoʻonui iā lākou i loko o ka hale hana. A laila ua hana ʻo Zhang Wei i ka chemotherapy conditioning e hōʻemi i ka helu o nā lymphocytes e kū nei i loko o kona kino, e hoʻomākaukau ana no ka hoʻolauna ʻana o nā pūnaewele CAR-T. ʻO ka hope loa, ua hoʻokomo hou ʻia nā pūnaewele CAR-T i hoʻololi ʻia i loko o ke kino o Zhang Wei.

I ka wā mua o ka mālama ʻana, ua luhi iki ʻo Zhang Wei, akā ʻelua pule ma hope mai, ua hoʻomaka kona mau hōʻailona e hoʻomaikaʻi nui ʻia. Ua emi nui ʻia ka ptosis a me ka ʻike maka pohihihi, a ua hoʻi mālie mai kona ikaika. I hoʻokahi mahina ma hope mai, ua hoʻomaikaʻi ʻia kona pono hana, a hiki iā ia ke hoʻi hou i nā hana maʻamau o kēlā me kēia lā. ʻEkolu mahina ma hope o ka mālama ʻana, ua aneane nalowale loa nā hōʻailona o Zhang Wei, a ʻaʻole pono hou iā ia nā lāʻau lapaʻau ma mua. Ua hōʻike nā hoʻokolohua ma hope aku ua maikaʻi ke ʻano o kona ʻōnaehana pale, me ka ʻole o nā hopena ʻino a i ʻole nā ​​​​hōʻailona o ka hoʻi hou ʻana o ka maʻi.

Ma o ka lāʻau lapaʻau CAR-T cell, ua kāohi nui ʻia ka myasthenia gravis o Zhang Wei, e hoʻomaikaʻi nui ana i kona ʻano ola a me kona hiki ke hana. Hāʻawi kēia lāʻau lapaʻau i ka manaʻolana hou i nā poʻe maʻi myasthenia gravis he nui.