I-Myasthenia gravis-01

Ibali Lonyango lweMyasthenia Gravis kaZhang Wei

UZhang Wei, injineli yesoftware eneminyaka engama-32 ubudala, waqala ukuba neempawu ze-myasthenia gravis (MG) kwiminyaka emibini eyadlulayo. Ekuqaleni, wayene-ptosis (iinkophe ezigobileyo) kunye nokubona okufipheleyo, kodwa iimpawu zakhe zaya zisiba mandundu ngokuhamba kwexesha, nto leyo eyakhokelela ekubeni buthathaka kwemisipha ngokubanzi okwachaphazela kakhulu umsebenzi wakhe kunye nobomi bakhe bemihla ngemihla. Nangona wayefumana unyango olwahlukeneyo, kuquka amayeza e-anticholinesterase, amayeza okunciphisa amajoni omzimba, kunye ne-immunoglobulin efakwa kwi-intravenous, iimpawu zakhe zaqhubeka kwaye zaziphinda-phinda.

Njengoko unyango lwesintu lungazange luphumelele, oogqirha bacebisa ukuba uZhang Wei azame indlela entsha yonyango: unyango lweeseli ze-CAR-T. Olu nyango lutsha lusebenzisa ubunjineli bemfuza ukuguqula iiseli ze-T zesigulana, nto leyo ebenza bakwazi ukujolisa nokususa iiseli ezingaqhelekanga ezinxulumene nesifo.

Emva kovavanyo olucokisekileyo, uZhang Wei wabonwa efanelekile kunyango. Oogqirha baqale bahlula ii-T cells emzimbeni wakhe baza bazitshintsha ngokwemfuza baza bazikhulisa kwilebhu. Emva koko uZhang Wei wenziwa i-chemotherapy yokulungisa imeko ukuze kuncitshiswe inani lee-lymphocytes ezikhoyo emzimbeni wakhe, elungiselela ukungeniswa kwee-CAR-T cells. Ekugqibeleni, ii-CAR-T cells eziguquliweyo zabuyiselwa emzimbeni kaZhang Wei.

Ngexesha lokuqala konyango, uZhang Wei wadinwa okwethutyana, kodwa emva kweeveki ezimbini, iimpawu zakhe zaqala ukuphucuka kakhulu. I-ptosis kunye nokungaboni kakuhle kwancipha kakhulu, kwaye amandla akhe abuya kancinci kancinci. Emva kwenyanga, ukusebenza kakuhle kwakhe emsebenzini kwaphucuka, kwaye wakwazi ukuqhubeka nemisebenzi yemihla ngemihla eqhelekileyo. Emva kweenyanga ezintathu emva konyango, iimpawu zikaZhang Wei zaziphantse zaphela ngokupheleleyo, kwaye wayengasadingi amayeza angaphambili. Uvavanyo olulandelayo lubonise ukuba inkqubo yakhe yomzimba yokuzikhusela yayikwimeko entle, kungekho miphumo mibi okanye iimpawu zokubuyela kwesifo kwakhona.

Ngonyango lweeseli zeCAR-T, i-myasthenia gravis kaZhang Wei yalawulwa kakhulu, yaphucula kakhulu umgangatho wobomi bakhe kunye namandla akhe okusebenza. Olu nyango lunika ithemba elitsha kwizigulane ezininzi ezine-myasthenia gravis.