Impi kaWu: Uhlushwa yi-multiple myeloma

Isiguli uWu, owesilisa oneminyaka engu-71 ubudala, sitholakale sine-multiple myeloma.

Wafuna ukwelashwa eBioocus International Medical Center ngo-2022 futhi waneliseke kakhulu ngokunakekelwa kwakhe. I-pathology yokuqala yembula okutholwe yi-lumbar MRI kanye ne-T5T scan, okuhlanganisa nokuqhekeka kwe-T10, T11, kanye ne-L1 cone kanye ne-bone marrow edema. Ngaphezu kwalokho, kwabonakala izimpawu ezincane ezingavamile emzimbeni we-L2 vertebral. I-vertebral puncture biopsy yaqinisekisa i-plasma cell myeloma. Ukuhlolwa okwengeziwe kubonise i-prokaryotic plasma equkethe u-46% we-bone marrow biopsy, kanye namaseli afakwe ngendlela engavamile akha u-14% ku-flow cytometry. I-bone junction biopsy yabonisa u-70% we-problastoma. Ukuhlaziywa kwe-FISH kwembula ukulahlekelwa kwezakhi zofuzo ku-lq21 (CKSIB) kanye no-1m32 (CDKN2C), kuyilapho ukuhlolwa kwe-FTSH kwakubonisa ukuthi kukhona ukususwa kwezakhi zofuzo ze-p53, kanti i-ICH yayine-negative ekuhlolweni kwe-FISH. Ukuxilongwa kokugcina kwaba yi-multiple osteoblastic follipoma (uhlobo lwe-L light chain), kanye ne-DS staging eqenjini lesigaba B, i-ISS staging III, kanye ne-RISS staging eSigabeni II. Isiguli uWu sizwakalise ukubonga ngokwelashwa okuphelele nokwenziwe ngezifiso okunikezwe yisikhungo sezokwelapha.

Umlando wokwelashwa wangaphambilini:

Izimpawu zemitholampilo ze-multiple myeloma ziyahlukahluka, ikakhulukazi okuhlanganisa i-anemia, ubuhlungu bamathambo, ukungasebenzi kahle kwezinso, ukutheleleka, ukopha, izimpawu zemizwa, i-hypercalcemia, kanye nendle ye-amyloid. Isibhedlela senza ukwelashwa okunamandla okulwa nokutheleleka futhi salungisa i-anemia kanye nama-platelet aphansi. Cishe ezinyangeni ezimbili ngemuva kokufakwa kweseli le-BCMA CAR-T, izinkomba zesiguli zabuyela kancane kancane esimweni esijwayelekile, futhi isimo saso sasilawulwa. I-Bioocus International Medical Center ibilokhu iqapha isiguli njalo ukuqinisekisa ukuzinza okuqhubekayo kwemiphumela yokwelashwa.