Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Halala! Isiguli saseNorway, uBjørn Simensen, esineminyaka emibili yokululama okuqhubekayo.

Indoda eneminyaka engu-67 ubudala uBjørn Simensen yafika esibhedlela ngoSepthemba 2017 inezikhalazo zokukhwehlela nobuhlungu besifuba. Ngesikhathi sokuhlolwa kwayo, kwatholakala ukuthi ine-multiple myeloma (IgG lambda) ISS-II. Isiguli sathola imijikelezo emi-4 ye-bortezomib, i-lenalidomide kanye ne-dexamethasone chemotherapy. Ngemva kwemijikelezo emi-4 iphrotheni yakhe ye-M yayingaphansi kuka-1g/l. Isiguli sabe sesiphumile ekunakekelweni kwe-lenalidomide (amasonto angu-10mg qdx3 ngenyanga m) aqhubeka nayo iminyaka emi-2 eyalandela. Yahlala ingenasifo kwaze kwaba yihlobo lika-2021 lapho ngesikhathi sokuhlolwa kokuxolelwa kwatholakala ukuthi iphrotheni ye-M ephakanyisiwe (5g/l). I-Lenalidomide yamiswa futhi yaqalwa ukwelashwa kwe-carfilzomib kanye ne-daratumumab chemotherapy kusukela ngo-Okthoba kuya kuDisemba 2021. Kodwa-ke, ukwelashwa kwe-chemotherapy akusebenzanga kahle futhi i-BM MRD yangemva kwe-chemo yayine-positive.

UMnu. Bjørn Simensen wabonakala okokuqala esikhungweni sethu se-CGT ngomhlaka-14 kuNhlolanja 2022. I-BM MRD yakhe ibonise amaphesenti angu-0.25 amangqamuzana e-plasma angajwayelekile. I-IEF ibonise ukuthi i-IgG kanye ne-M protein yayingu-3 g/l. I-PET-CT Scan ibonise ukwanda kokumuncwa kwe-testis ikakhulukazi elungile okwakhuliswa lapho kuhlolwa. Kwenziwa i-biopsy yama-testicular eyabonisa amangqamuzana e-plasma anobungozi. Isiguli sakhethwa ukwelashwa ngamaseli e-CART. Ukulungiswa kwangaphambi kwesikhathi kwenziwa nge-fludarabine kanye ne-cyclophosphamide izinsuku ezi-3. Amaseli e-CAR-T afakwa ngosuku lwe-0 (4/3/2222). Umthamo onikeziwe wawungu-0.5X10^6 /kg. Ngemva kokufakwa, isiguli saba nomkhuhlane we-neutropenia owalawulwa ngama-antibiotic e-iv. Ukuvuvukala kwama-testicular kwesokudla kwehla kancane kancane kwaba usayizi ojwayelekile. Ngosuku lwama-28 ukuhlolwa kwe-BM kwaba negative kumaseli e-plasma. Isiguli sakhishwa eLu Daopei ngokulandelwa njalo esikhungweni se-hematology edolobheni lakubo.