Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Ngā mihi nui! He tūroro nō Nōwei, ko Bjørn Simensen, kua rua tau te roa o tōna whakaoranga.

I te marama o Hepetema 2017, i tae mai a Bjørn Simensen, he tāne 67-tau te pakeke, ki te hōhipera me ngā amuamu mō te mare me te mamae o te uma. I tana tirotiro, i kitea he mate myeloma maha (IgG lambda) ISS-II tōna. E 4 ngā huringa o te bortezomib, lenalidomide me te dexamethasone chemotherapy i whiwhi te tūroro. I muri i ngā huringa e 4, he iti iho i te 1g/l tana pūmua M. Kātahi ka tangohia te lenalidomide maintenance (10mg qdx3 wiki ia marama m) e te tūroro, ā, i mau tonu ia mō ngā tau e 2 e whai ake nei. I noho kore mate ia tae noa ki te raumati o te tau 2021, ā, i te wā o te aromatawai whakaora, i kitea he pikinga o te pūmua M (5g/l) i a ia. I mutu te Lenalidomide, ā, i tīmatahia ia ki te carfilzomib me te daratumumab chemotherapy mai i Oketopa ki Tīhema 2021. Heoi, kāore i whai hua te chemotherapy, ā, i pai te BM MRD i muri i te chemotherapy.

I te 14 o Pēpuere 2022, i kitea tuatahitia a Mr Bjørn Simensen i tō mātou pokapū CGT. I whakaatuhia e tana BM MRD he 0.25 ōrau o ngā pūtau plasma rerekē. I whakaatuhia e te IEF ko te IgG me te pūmua M he 3 g/l. I whakaatuhia e te PET-CT Scan te pikinga o te tango i roto i te testis, inā koa ko te mea matau i whakanuia hoki i te tirotiro. I mahia he koiora testicular i whakaatuhia ai ngā pūtau plasma kino. I tīpakohia te tūroro mō te rongoā pūtau CART. I mahia te whakatikatika mua ki te fludarabine me te cyclophosphamide mō ngā rā e 3. I werohia ngā pūtau CAR-T i te rā 0 (4/3/2222). Ko te horopeta i hoatu ko 0.5X10^6 /kg. I muri i te werohanga, i pāngia te tūroro e te kirika neutropenia i whakahaeretia me ngā paturopi iv. I heke haere te pupuhi o te testicular matau ki te rahi noa. I te rā 28, i kitea he kino te whakamātautau BM mō ngā pūtau plasma. I tukuna te tūroro mai i Lu Daopei me te aroturuki auau i te pokapū hematology i tōna tāone.