Bjørn Simensen----Multiple Myeloma (IgG lambda) ISS-II

Siyavuyisana nawe! Isigulana saseNorway, uBjørn Simensen, sifumene iminyaka emibini yokuxolelwa.

Indoda eneminyaka engama-67 ubudala uBjørn Simensen yafika esibhedlele ngoSeptemba 2017 inezikhalazo zokukhwehlela kunye neentlungu zesifuba. Ngexesha lotyando lwakhe, kwafunyaniswa ukuba une-multiple myeloma (IgG lambda) ISS-II. Isigulana safumana imijikelo emi-4 ye-bortezomib, i-lenalidomide kunye ne-dexamethasone chemotherapy. Emva kwemijikelo emi-4 iprotheyini yakhe ye-M yayingaphantsi kwe-1g/l. Isigulana saphuma kwi-lenalidomide (iiveki ezili-10mg ngenyanga m) awaqhubeka nayo iminyaka emi-2 elandelayo. Sahlala singenasifo de kwaba sehlotyeni lika-2021 xa ngexesha lovavanyo lokukhululwa kwafunyaniswa ukuba sineprotheyini ye-M ephezulu (5g/l). I-Lenalidomide yayekwa kwaye waqaliswa kwi-carfilzomib kunye ne-daratumumab chemotherapy ukususela ngo-Okthobha ukuya kuDisemba 2021. Nangona kunjalo, i-chemotherapy ayizange isebenze kwaye i-BM MRD emva kwe-chemo yayine-positive.

UMnu. Bjørn Simensen wabonwa okokuqala kwiziko lethu le-CGT nge-14 kaFebruwari 2022. I-BM MRD yakhe ibonise iipesenti ezingama-0.25 zeeseli zeplasma ezingaqhelekanga. I-IEF ibonise ukuba i-IgG kunye ne-M protein yayiyi-3 g/l. I-PET-CT Scan ibonise ukwanda kokufunxwa kwi-testis ngakumbi ekunene eyathi yandiswa xa kuhlolwa. I-biopsy yamatyhalarha yenziwa eyabonisa iiseli zeplasma ezinobungozi. Isigulana sakhethwa ukuba sisetyenziswe kwi-CART cell therapy. Ukulungiswa kwangaphambili kwenziwa nge-fludarabine kunye ne-cyclophosphamide kangangeentsuku ezi-3. Iiseli ze-CAR-T zafakwa ngomhla we-0 (4/3/2222). Idosi enikiweyo yayiyi-0.5X10^6 /kg. Emva kokufakwa, isigulana sasine-neutropenia fever eyalawulwa ngee-antibiotics ze-iv. Ukudumba kwamatyhalarha asekunene kwehla kancinci kancinci kwaba kubukhulu obuqhelekileyo. Ngomhla wama-28 uvavanyo lwe-BM lwalungekho kwiiseli zeplasma. Isigulana sakhutshwa eLu Daopei ngokulandelela rhoqo kwiziko le-hematology kwisixeko saso.