Nkhondo ya Wu: Kuvutika ndi matenda a multiple myeloma

Wodwala Wu, mwamuna wazaka 71, adapezeka ndi matenda a multiple myeloma.

Anapita ku Bioocus International Medical Center mu 2022 ndipo wakhutira kwambiri ndi chisamaliro chake. Matenda oyamba adawonetsa zomwe zapezeka mu lumbar MRI ndi T5T scan, kuphatikizapo kusweka kwa T10, T11, ndi L1 cone ndi edema ya bonemarrow. Kuphatikiza apo, zizindikiro zazing'ono zosazolowereka zidawonedwa m'thupi la vertebral la L2. Biopsy ya vertebral puncture idatsimikizira plasma cell myeloma. Mayeso ena adawonetsa prokaryotic plasma yokhala ndi 46% ya bonemarrow biopsy, ndi maselo osazolowereka omwe amapanga 14% mu flow cytometry. Biopsy ya mafupa olumikizana idawonetsa 70% problastoma. Kusanthula kwa FISH kudawonetsa kutayika kwa majini mu lq21 (CKSIB) ndi 1m32 (CDKN2C), pomwe mayeso a FTSH anali ndi zotsatira zabwino pakuchotsedwa kwa majini a p53, ndipo ICH inali yoyipa mu mayeso a FISH. Kuzindikira komaliza kunali multiple osteoblastic follipoma (mtundu wa unyolo wa L), ndi DS staging mu gulu la siteji B, ISS staging III, ndi RISS staging mu Gawo II. Wodwala Wu adayamikira chithandizo chokwanira komanso chapadera chomwe adapereka kuchipatala.

Mbiri yakale ya chithandizo:

Zizindikiro zachipatala za multiple myeloma ndi zosiyanasiyana, makamaka kuphatikizapo kuchepa kwa magazi m'thupi, kupweteka kwa mafupa, kulephera kugwira ntchito bwino kwa impso, matenda, kutuluka magazi, zizindikiro za mitsempha, hypercalcemia, ndi ndowe za amyloid. Chipatalachi chinapereka chithandizo champhamvu cholimbana ndi matenda ndipo chinakonza kuchepa kwa magazi m'thupi ndi kuchepa kwa ma platelet. Patatha miyezi iwiri kuchokera pamene BCMA CAR-T inalowa m'thupi, zizindikiro za wodwalayo zinabwerera mwakale, ndipo mkhalidwe wake unayamba kukhazikika. Bioocus International Medical Center yakhala ikuyang'anira wodwalayo nthawi zonse kuti atsimikizire kuti zotsatira za chithandizocho zikukhazikika.