Khansa ya m'magazi ya Lymphoblastic (T-ALL)-08

Yesheng wa ku Fujian anati, "Ndikanadziwa za CAR-T ku BIOOCUS Medical Group, ndikanabwera msanga."

Mu Seputembala 2017, Yesheng adayamba kutupa pankhope, komwe pang'onopang'ono kudafalikira ndikusakanikirana ndi mabala. Pofika pa February 28, 2018, kufufuza kwa mafupa kunatsimikizira kuti panali "acute T-cell lymphoblastic leukemia" pambuyo pa mankhwala ambiri a chemotherapy, komanso kufufuza pang'onopang'ono za zotsatira zoyipa. Mankhwala onse adayimitsidwa mu June 2019.

Mu Meyi 2021, Yesheng adapezeka ndi ziphuphu m'dera la mkamwa ndi m'khosi komanso ma lymph nodes okulirapo a khosi. Kuwunikanso kwa mafupa kunatsimikizira kuti khansa ya m'magazi yabwereranso. Pa Meyi 28, Yesheng adasamutsidwira ku Dipatimenti Yachiwiri ya Hematology kuti akalowe. Pambuyo poyesedwa mokwanira, matendawa adasinthidwa kukhala "acute leukemia (T/myeloid biphenotypic)."

Kulandira mankhwala a chemotherapy kamodzi kokha sikunapangitse kuti mafupa achepe. Pa Julayi 27, Yesheng adalandira chithandizo cha maselo a CD7 CAR-T, kenako adalandira chithandizo cha chemotherapy pamodzi ndi chithandizo cha maselo a autologous CD7 CAR-T. Patatha masiku khumi ndi asanu kuchokera pamene adalandira chithandizo, kufufuza kwa mafupa kunasonyeza kuti panali matenda otsala, ndipo panalibe zotsatirapo zoyipa za cytokine release syndrome (CRS) ya grade 1 ndipo panalibe zotsatirapo zoyipa za dongosolo la mitsempha.