Khansa ya m'magazi ya Lymphoblastic (T-ALL)-10

Mnyamata wazaka 13 dzina lake Yangyang wochokera ku Panzhihua, Sichuan Province, adachitidwa opaleshoni ya CAR-T kenako adamuika m'thupi lake.

Poyamba Yangyang anali ndi "mabala obalalika m'thupi lonse limodzi ndi kutopa" pa Epulo 12, 2021. Anapezeka ndi matenda a acute lymphoblastic leukemia (T-cell subtype) omwe anali ndi kutuluka magazi m'mitsempha ya m'mutu komanso matenda a m'mapapo omwe adatsimikiziridwa ndi kuyezetsa kwa MICM ya m'mafupa kuchipatala chachikulu ku Chongqing. Analandira chithandizo cha chemotherapy katatu kuchipatala china, koma m'mafupa sanachiritsidwe. Pofika kumayambiriro kwa mwezi wa June, miyendo yonse iwiri ya m'munsi inayamba kufooka ndipo sankatha kuyenda.

Pa Julayi 1, 2021, Yangyang adalowa mu Dipatimenti yathu ya Hematology Ward 2. Analembetsa mu mayeso azachipatala a CD7 CAR-T pa Julayi 8 ndipo adalandira chithandizo cha maselo a CD7 CAR-T pa Julayi 26 kuti alandire chithandizo cha immunotherapy. Patatha masiku khumi ndi asanu ndi limodzi kuchokera pamene adapatsidwa chithandizo, mawonekedwe a mafupa adawonetsa kuti achotsedwa, ndipo flow cytometry idawonetsa kuti 0.07% ya ma lymphoblasts osakhwima omwe anali ndi vuto la khansa anali okayikitsa. Pambuyo pa chithandizo cha thupi, adayambanso kuyenda payekha. Pofika tsiku la 31 atapatsidwa chithandizo, mafupa ake adachira kwathunthu.

Pakadali pano, Yangyang wasamutsidwira ku Ward 6 ya Dipatimenti Yosintha Mafupa kuti akalandire chithandizo china. Dr. Hai wochokera ku Ward 6 anati Yangyang wakhala akugwirizana ndi dokotala komanso ali ndi chiyembekezo panthawi yonse ya chithandizo chake. Anasamutsidwa maselo oyambira a magazi (kuchokera kwa abambo ake) pa Seputembala 28. Zinthu zomwe zinapangidwa ndi ogwira ntchito ku Dipatimenti Yosintha Magazi kuti amusamutsire magazi zinayamikiridwa kwambiri.

Odwalawa, asanalembetsedwe mu kafukufuku wa CD7 CAR-T, adawonetsa zizindikiro zosiyanasiyana monga kubwereranso kwa matenda pambuyo poika chiwalo, T/myeloid dual expression, refractory/resistant acute T-cell leukemia, central nervous system leukemia, intracranial nervous hemorrhage, ndi matenda a m'mapapo. Pambuyo poyesa ndi kulandira chithandizo cha CD7 CAR-T, onse adachira kwathunthu, kukwaniritsa zotsatira zomwe amayembekezera.

Malo athu ochiritsira matenda a CGT afufuza mozama za chithandizo cha CAR-T ndipo apeza luso lochuluka pochiza CRS. Kwa ambiri omwe adatenga nawo mbali, zotsatira zoyipa kwambiri zinali kutentha thupi kwambiri. "Nditha kuchira kwathunthu, kotero kutentha thupi si kanthu! Ndikufuna kuti anthu ambiri adziwe kuti BIOOCUS ingathe kuchita CAR-T!" anatero Yangyang wochokera ku Fujian atatuluka m'chipatala.