Te Mate Pūkahukahu Lymphoblastic Whakapeka (T-ALL)-10

I whiwhihia he CAR-T ki tētahi tamaiti 13-tau te pakeke nō Panzhihua, Porowini o Sichuan, ā, i muri mai ka whakatōkia he pūtau ki roto i tōna tinana.

I te 12 o Paenga-whāwhā, 2021, i puta tuatahi mai a Yangyang me ngā "marutanga marara puta noa i te tinana me te ngenge". I kitea tōna mate pukupuku toto lymphoblastic acute (momo pūtau-T) me te toto toto i roto i te angaanga me te mate pūkahukahu i whakaūtia e te whakamātautau MICM hinu wheua i tētahi hōhipera nui i Chongqing. E toru ngā huringa o te chemotherapy i mahia ki a ia i tētahi atu hōhipera, engari kāore i pai te hinu wheua. I te tīmatanga o Hune, ka ngoikore ia i ngā waewae o raro e rua, ā, kāore i taea e ia te hikoi.

I te 1 o Hūrae, 2021, i whakaurua a Yangyang ki tā mātou Tari Hematology Wāhanga 2. I whakauru ia ki te whakamātautau haumanu CD7 CAR-T i te 8 o Hūrae, ā, i whiwhi ia i te werohanga pūtau CD7 CAR-T autologous i te 26 o Hūrae mō te immunotherapy. Tekau mā ono ngā rā i muri i te werohanga, i whakaatuhia te āhua o te hinu wheua kia murua, ā, i whakaatuhia e te flow cytometry he 0.07% ngā lymphoblast T kino kino whakapae. I muri i te whakaora tinana, i hoki anō ia ki te kaha ki te hikoi takitahi. I te rā 31 i muri i te werohanga, kua murua katoatia tana hinu wheua.

I tēnei wā, kua whakawhitia a Yangyang ki te Wāhanga 6 o te Tari Whakatō Huango Wheua mō ētahi atu maimoatanga. I kī a Tākuta Hai o te Wāhanga 6, he kaha te mahi tahi a Yangyang, ā, he tino hihiri hoki ia puta noa i tana maimoatanga. I whiwhi ia i te whakawhitinga pūtau take hematopoietic allogeneic (mai i tōna matua) i te 28 o Hepetema. I tino maioha ki ngā āhuatanga i hangaia e ngā hoa mahi o te Tari Hematology mō tana whakawhitinga hononga.

I mua i te whakaurunga ki te whakamātautau haumanu CD7 CAR-T, i puta mai ēnei tūroro me ngā tohu rerekē pērā i te hokinga mai i muri i te whakawhitinga, te whakaaturanga takirua T/myeloid, te mate pukupuku T-pūtau ātete/aukati, te mate pukupuku pūnaha io matua, te totohu i roto i te angaanga, me te mate pūkahukahu. Whai muri i te aromatawai me te maimoatanga ki te rongoā CD7 CAR-T, i tutuki katoa te whakaoranga, me te tutuki i ngā putanga e tumanakohia ana.

Kua kaha te tūhuratanga a tā mātou pokapū CGT i te mara o te rongoā CAR-T, ā, kua kohia e rātou he nui ngā wheako ki te whakahaere i te CRS. Mō te nuinga o ngā kaiuru, ko te pānga kino rawa atu ko te kirika nui. "Ka taea e au te whakatutuki i te murunga katoa, nō reira kāore he aha te kirika! E hiahia ana ahau kia mōhio te tini o te tangata ka taea e BIOOCUS te mahi CAR-T!" te kī a Yangyang nō Fujian i te putanga mai i te hōhipera.