Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)-10

Mukomana ane makore gumi nematatu ekuberekwa anonzi Yangyang anobva kuPanzhihua, Sichuan Province, akavhiyiwa CAR-T ndokuzovhiyiwa bhiriji.

Yangyang akatanga "kukuvadzwa kwakapararira mumuviri wese pamwe nekuneta" musi wa12 Kubvumbi, 2021. Akaonekwa aine chirwere che acute lymphoblastic leukemia (T-cell subtype) nekubuda ropa mukati memusoro uye hutachiona hwemapapu hwakasimbiswa nekuongororwa kwebone marrow MICM kuchipatara chikuru muChongqing. Akaongororwa katatu kechemotherapy pane chimwe chipatara, asi bone marrow haina kupindura. Pakutanga kwaChikumi, akatanga kushaya simba mumakumbo ese ari maviri uye aisagona kufamba.

Musi wa1 Chikunguru 2021, Yangyang akapinda muchipatara cheHematology Department Ward 2. Akanyoresa muongororo yekiriniki yeCD7 CAR-T musi wa8 Chikunguru uye akapihwa autologous CD7 CAR-T cell infusion musi wa26 Chikunguru kuti apihwe immunotherapy. Mazuva gumi nematanhatu mushure mekupihwa, morphology yebone marrow yakaratidza relieve, uye flow cytometry yakaratidza 0.07% monkey T immature T lymphoblasts inofungirwa kuti ine chirwere. Mushure mekupihwa physiotherapy, akakwanisa kufamba ari ega. Pakazosvika zuva rechi31 mushure mekupihwa, bone marrow yake yakawana relieve yakakwana.

Parizvino, Yangyang akatamisirwa kuWard 6 yeBone Marrow Transplantation Department kuti anorapwa zvakare. Dr. Hai vekuWard 6 vakati Yangyang anga achibatsirana uye aine tariro panguva yese yekurapwa kwake. Akazoiswa masero eropa anokonzerwa neallogeneic hematopoietic (kubva kuna baba vake) musi wa28 Gunyana. Mamiriro ezvinhu akagadzirwa nevamwe vake muHematology Department ekuti aisirwe bridging transplant akakosheswa zvikuru.

Varwere ava, vasati vapinda muchirongwa cheCD7 CAR-T, vakaratidza zviratidzo zvakasiyana-siyana zvakaita sekudzoka kwechirwere mushure mekuisirwa ropa, T/myeloid dual expression, refractory/resistant acute T-cell leukemia, central nervous system leukemia, kubuda ropa mukati memusoro, uye hutachiona hwemapapu. Mushure mekuongororwa nekurapwa neCD7 CAR-T therapy, vese vakawana zororo rakazara, vachisangana nemigumisiro yaitarisirwa.

Nzvimbo yedu yeCGT yakaongorora zvakanyanya nyaya yekurapa neCAR-T uye yakaunganidza ruzivo rwakakura mukurapa CRS. Kune vazhinji vevatori vechikamu, mhedzisiro yakanyanya yaive fivha yakanyanya. "Ndinogona kuwana zororo rakazara, saka fivha haisi chinhu! Ndinoda kuti vanhu vakawanda vazive kuti BIOOCUS inogona kuita CAR-T!" akadaro Yangyang wekuFujian paakabuda muchipatara.