Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)-05

Kuregererwa kweMurwere weT-ALL Akadzoka muchipatara ane Leukemia yeCentral Nervous System Mushure mekurapwa neCAR-T

Nyaya iyi inosanganisira mukomana ane makore gumi nematanhatu ekuberekwa anobva kuChamhembe kwakadziva kumabvazuva kweChina, ane dambudziko releukemia rave richinetsa kubvira paakaonekwa aine chirwere ichi gore rapfuura.

Musi wa8 Mbudzi, 2020, Dawei (zita rekunyepedzera) akaenda kuchipatara chemuno nekuda kwekuoma kwechiso, mapundu, uye muromo wakakombama. Akaonekwa aine "acute lymphoblastic leukemia (T-cell type)." Mushure mekupihwa chemotherapy kamwe chete, MRD (minimum residual disease) haina kuonekwa zvakanaka, yakateverwa nechemotherapy yenguva dzose. Munguva iyi, kupwanywa kwemapfupa, kupwanywa kwelumbar, uye kubaiwa majekiseni mukati memuviri hazvina kuratidza kusarongeka.

Musi wa6 Chivabvu, 2021, kurohwa kwechiuno nejekiseni remukati memusana kwakaitwa, uye ongororo ye cerebrospinal fluid (CSF) yakasimbisa "central nervous system leukemia." Izvi zvakateverwa nemaitiro maviri ekurapa chemotherapy nguva dzose. Musi wa1 Chikumi, kurohwa kwechiuno neCSF ongororo yakaratidza masero asina kukura. Mamwe maburi matatu emusana nejekiseni remukati memusana akapihwa, bvunzo yekupedzisira yeCSF isina kuratidza masero ebundu.

Musi wa7 Chikunguru, Dawei akaona ziso rake rekurudyi risisina kuona zvakanaka, asi rakazopedzisira rava kuona chiedza chete. Mushure mekupiwa chemotherapy yakawedzerwa, ziso rake rekurudyi rakadzokera pakuona kwaro.

Musi wa5 Nyamavhuvhu, ziso rake rekurudyi rakatanga kuona zvisina kunaka zvakare, zvikaita kuti aonekwe zvizere, uye ziso rake rekuruboshwe rakatanga kusviba. Kubva musi wa10 kusvika 13 Nyamavhuvhu, akarapwa neradiotherapy yeuropi hwese nemusana (TBI), iyo yakadzoreredza kuona muziso rake rekuruboshwe, asi ziso rekurudyi rakaramba risingaoni. Musi wa16 Nyamavhuvhu, MRI scan yeuropi yakaratidza kuvandudzika kudiki mukukora kwetsinga yemaziso yekurudyi uye chiasm, uye kuwedzerwa kwakaonekwa. Hapana zviratidzo zvisina kujairika kana kuwedzerwa kwakawanikwa muuropi parenchyma.

Panguva iyi, mhuri yakanga yagadzirira kuisirwa mamongo, ichingomirira mubhedha muwadhi yekuisirwa mamongo. Zvinosuwisa kuti, kuongororwa kwakaitwa nguva dzose vasati vaisirwa mamongo kwakaratidza matambudziko akaita kuti kusakwanisa kuisirwa mamongo.