Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)-07

Musikana wekuMiao anowana zororo rakazara mushure mekurapwa neCAR-T mushure mekudzokera kuchipatara mushure mekuisirwa mwana.

Amei, mudzidzi wepashure pechikoro anobva kuHunan werudzi rweMiao, akaburitsa mapepa maviri eSCI. Musi wa2 Kubvumbi 2020, akapinzwa muchipatara cheprovince nekuda kwefivha yaidzokororwa. Kuongororwa kwemapfupa kwakaratidza kuti aive nechirwere cheacute lymphoblastic leukemia (T-ALL). Mushure mekurapwa kakawanda nechemotherapy kuchipatara chekunze, mapfupa ake akaramba ari mudumbu. Musi wa2 Mbudzi 2020, akaisirwa masero eropa allogeneic hematopoietic kuchipatara chedu (mukoma nehanzvadzi, HLA 7/10 match). Mushure mekuisirwa masero, masero aya akabatanidzwa zvinobudirira, uye kuongororwa kwemapfupa emapfupa kwakatevera kwakaratidza kuti anoramba ari mudumbu.

Musi wa16 Chikumi, 2021 (mwedzi 7 mushure mekuisirwa mwana), kuongororwa kwakaitwa nguva dzose kwakaratidza kuti chirwere chake cheleukemia chakanga chadzoka zvakare. Kurapwa kwakazotevera kwakakundikana kudzora chirwere ichi, uye akatanga pneumonia nehutachiona hweherpes, nemaronda emuromo anorwadza zvichiita kuti kumedza kuome. Akapinda muwadhi yechipiri yedhipatimendi rehematology uye akanyoreswa muongororo yekiriniki yeCD7 CAR-T.

Chikwata chekurapa chakapa mushonga wekudzivirira hutachiona, kuderedza marwadzo, uye kuwedzerwa ropa nemaplatelet zvakanyanya. Nekuda kwehuwandu hwakawanda hwemapundu (80% yekuputika mumongo wemapfupa uye 97% yekuputika muropa rekunze), hazvina kukwanisa kutora masero ake. Malymphocyte eropa ekunze kubva kumupi (mukoma wake) akatorwa ndokutumirwa kukambani ye biotech yekudzidzisa CAR-T cell culture.

Musi wa10 Nyamavhuvhu, 2021, masero eCD7 CAR-T anobva kune vanopa mishonga akadzorerwa. Mushure mekudzorerwa, masero eCAR-T akawedzera kusvika pa54.64% muropa, nefivha chete uye pasina significant cytokine release syndrome (CRS) kana graft-versus-host disease (GVHD). Kuongororwa kwemapfupa pazuva rechi16 mushure mekudzorerwa kwakaratidza kurerukirwa kwakazara, ne54.13% masero eCAR-T mumapfupa. Pazuva rechi36, mapfupa akaramba achirerukirwa kwenguva refu. Pari zvino, pfungwa dzake, hope, uye chido chekudya zvakanaka, uye ari kupora zvakanaka.