Kab mob qog ntshav Lymphoblastic loj heev (T-ALL)-07

Ib tug ntxhais Miao tau zoo tag nrho tom qab kev kho mob CAR-T tom qab rov qab mob dua tom qab hloov hlwb.

Amei, ib tug tub ntxhais kawm tiav qib siab los ntawm Hunan ntawm haiv neeg Miao, tau luam tawm ob daim ntawv SCI. Thaum Lub Plaub Hlis 2, 2020, nws tau raug xa mus rau tsev kho mob hauv xeev vim muaj mob kub taub hau rov qab los. Kev kuaj pob txha tau kuaj pom tias nws muaj mob leukemia lymphoblastic (T-ALL). Tom qab ntau zaus kho mob chemotherapy ntawm tsev kho mob sab nraud, nws cov pob txha tseem zoo. Thaum Lub Kaum Ib Hlis 2, 2020, nws tau hloov hlwb hlwb allogeneic hematopoietic ntawm peb lub tsev kho mob (kwv tij rau muam, HLA 7/10 sib phim). Tom qab hloov hlwb hlwb, cov hlwb tau cog tiav, thiab kev kuaj pob txha tom qab tau qhia tias zoo.

Thaum Lub Rau Hli 16, 2021 (7 lub hlis tom qab hloov ntshav), kev kuaj mob tsis tu ncua qhia tau tias nws rov qab mob ntshav dawb tag nrho. Kev siv tshuaj kho mob tom qab ntawd tsis ua haujlwm tswj tau tus kab mob, thiab nws tau mob ntsws thiab mob herpes, nrog rau mob qhov ncauj ua rau nyuaj rau nqos. Nws tau raug xa mus rau chav kho mob thib ob ntawm chav kho mob ntshav thiab tau koom nrog kev sim tshuaj CD7 CAR-T.

Cov kws kho mob tau muab kev kho mob tiv thaiv kev kis kab mob, txo qhov mob, thiab ntxiv ntshav thiab platelet ntau heev. Vim muaj ntau yam mob qog nqaij hlav (80% ntawm cov qog nqaij hlav tawg hauv cov pob txha thiab 97% ntawm cov qog nqaij hlav tawg hauv cov ntshav ncig), nws tsis tuaj yeem sau nws cov qe ntshav dawb. Cov qe ntshav dawb ntawm tus neeg pub dawb (nws tus kwv tij) tau sau thiab xa mus rau lub tuam txhab biotech rau kev cog qoob loo CAR-T.

Thaum Lub Yim Hli 10, 2021, cov hlwb CD7 CAR-T uas tau los ntawm cov neeg pub dawb tau rov ua dua. Tom qab rov ua dua, cov hlwb CAR-T tau nthuav dav mus txog 54.64% hauv cov ntshav ncig, tsuas yog kub taub hau thiab tsis muaj mob cytokine release syndrome (CRS) lossis graft-versus-host disease (GVHD) tseem ceeb. Kev kuaj pob txha hauv hnub 16 tom qab rov ua dua qhia tau tias muaj kev zam txim tag nrho, nrog rau 54.13% cov hlwb CAR-T hauv cov pob txha. Thaum hnub 36, cov pob txha tseem txuas ntxiv qhia txog kev zam txim tas mus li. Tam sim no, nws lub siab, kev pw tsaug zog, thiab kev noj mov zoo, thiab nws rov zoo.