Ciwon sankarar lymphoblastic mai tsanani (T-ALL)-07

Wata yarinya 'yar Miao ta sami cikakkiyar sauƙi bayan an yi mata maganin CAR-T bayan sake dawowa da aka yi mata dashen.

Amei, daliba ce ta digiri na biyu daga Hunan ta ƙabilar Miao, ta buga takardu biyu na SCI. A ranar 2 ga Afrilu, 2020, an kwantar da ita a wani asibiti na lardi saboda zazzabi mai yawan dawowa. Binciken ƙashi ya gano tana da cutar sankarar lymphoblastic mai tsanani (T-ALL). Bayan gwaje-gwaje da dama na chemotherapy a asibiti na waje, ƙashin ƙashinta ya ci gaba da warkewa. A ranar 2 ga Nuwamba, 2020, an yi mata dashen ƙwayoyin jini na allogeneic a asibitinmu (dan'uwa da 'yar'uwa, HLA 7/10 match). Bayan dashen, ƙwayoyin sun yi nasara, kuma gwajin bayan an yi musu ya nuna cewa an samu sauƙi.

A ranar 16 ga Yuni, 2021 (watanni 7 bayan dashen), wani bincike na yau da kullun ya nuna sake bullar cutar sankarar bargo. Maganin chemotherapy na baya-bayan nan ya kasa shawo kan cutar, kuma ta kamu da ciwon huhu da kuma kamuwa da cutar herpes, tare da ciwon baki mai zafi wanda ya sa haɗiye ta yi wahala. An kwantar da ita a sashen jini na biyu na sashen kula da jini kuma an yi mata gwajin asibiti na CD7 CAR-T.

Tawagar likitoci ta samar da maganin hana kamuwa da cuta, rage radadi, da kuma yawan zubar jini da platelets. Saboda yawan nauyin da ke kan ta (kashi 80% na fashewar a cikin bargo da kuma kashi 97% na fashewar a cikin jinin gefe), ba zai yiwu a tattara ƙwayoyin ta ba. An tattara ƙwayoyin lymphocytes na jini na gefe daga mai bayarwa (ɗan'uwanta) aka aika su zuwa wani kamfanin fasahar kere-kere don haɓaka ƙwayoyin CAR-T.

A ranar 10 ga Agusta, 2021, an sake haɗa ƙwayoyin CAR-T na CD7 da aka samo daga masu bayarwa. Bayan sake haɗawa, ƙwayoyin CAR-T sun faɗaɗa zuwa kashi 54.64% a cikin jinin gefe, tare da zazzabi kawai kuma babu wata muhimmiyar cutar sakin cytokine (CRS) ko cutar graft-versus-host (GVHD). Binciken ƙashi a rana ta 16 bayan sake haɗawa ya nuna cikakkiyar gafara, tare da 54.13% ƙwayoyin CAR-T a cikin ƙashin baya. A rana ta 36, ​​ƙashin ya ci gaba da nuna ci gaba da samun sauƙi. A halin yanzu, yanayin tunaninta, barcinta, da sha'awarta suna da kyau, kuma tana murmurewa sosai.