ʻO ka maʻi Leukemia Lymphoblastic ʻoʻoleʻa (T-ALL)-07

Ua hoʻokō ke kaikamahine Miao i ke kala piha ʻana ma hope o ka lāʻau lapaʻau CAR-T ma hope o ka hoʻi hou ʻana ma hope o ke kāpili ʻana.

ʻO Amei, he haumāna puka kula kiʻekiʻe mai Hunan o ka lāhui Miao, ua paʻi ʻo ia i ʻelua mau pepa SCI. Ma ʻApelila 2, 2020, ua hoʻokomo ʻia ʻo ia i kahi haukapila panalāʻau ma muli o ke kuni hou. Ua ʻike ʻia ʻo ia he leukemia lymphoblastic acute (T-ALL) ma ka nānā ʻana i ka iwi iwi ma muli o ka maʻi leukemia. Ma hope o nā papa hana chemotherapy he nui ma ka haukapila waho, ua noho mālie kona iwi iwi. Ma Nowemapa 2, 2020, ua hana ʻia ʻo ia i kahi hoʻoili cell stem hematopoietic allogeneic ma kā mākou haukapila (kaikuaʻana-i-ke-kaikuahine, HLA 7/10 match). Ma hope o ke kāpili ʻana, ua hoʻopili pono ʻia nā ʻāpana, a ua hōʻike nā nānā ʻana i ka iwi iwi i ke kala mau.

Ma Iune 16, 2021 (7 mau mahina ma hope o ke kāpili ʻana), ua hōʻike ʻia kahi nānā maʻamau i ka hoʻi hou ʻana o kona leukemia. ʻAʻole i hiki i ka chemotherapy ma hope ke kāohi i ka maʻi, a ua loaʻa iā ia ka maʻi pneumonia a me ka maʻi herpes virus, me nā ʻeha waha ʻeha e paʻakikī ai ke ale. Ua hoʻokomo ʻia ʻo ia i ka lua o ka ʻāpana hematology a ua kākau inoa ʻia i ka hoʻokolohua lapaʻau CD7 CAR-T.

Ua hāʻawi ke kime lapaʻau i ka lāʻau lapaʻau anti-maʻi ikaika, hoʻomaha ʻeha, a me nā hoʻoili koko a me nā platelet nui. Ma muli o ke kaumaha nui o ka puʻupuʻu (80% pahū i loko o ka iwi iwi a me 97% pahū i loko o ke koko peripheral), ʻaʻole hiki ke hōʻiliʻili i kāna mau cell. Ua hōʻiliʻili ʻia nā lymphocytes koko peripheral mai ka mea hāʻawi (kona kaikunāne) a hoʻouna ʻia i kahi hui biotech no ka moʻomeheu cell CAR-T.

Ma ʻAukake 10, 2021, ua hoʻokomo hou ʻia nā pūnaewele CD7 CAR-T i loaʻa mai ka mea hāʻawi. Ma hope o ka hoʻokomo hou ʻana, ua hoʻonui ʻia nā pūnaewele CAR-T i 54.64% i loko o ke koko peripheral, me ke kuni wale nō a ʻaʻohe cytokine release syndrome koʻikoʻi (CRS) a i ʻole ka maʻi graft-versus-host (GVHD). Ua hōʻike ka nānā ʻana o ka iwi iwi i ka lā 16 ma hope o ka hoʻokomo hou ʻana i ke koko i ka hoʻomaha piha ʻana, me 54.13% o nā pūnaewele CAR-T i loko o ka iwi iwi. I ka lā 36, ua hoʻomau ka iwi iwi i ka hōʻike ʻana i ka hoʻomaha mau. I kēia manawa, ua maikaʻi kona kūlana noʻonoʻo, hiamoe, a me ka makemake e ʻai, a ke hoʻōla maikaʻi nei ʻo ia.