I-Acute Lymphoblastic Leukemia (T-ALL)-07

Intombazana yaseMiao ifumana uxolo olupheleleyo emva konyango lwe-CAR-T emva kokubuyela umva emva kokufakelwa isibeleko.

U-Amei, umfundi ophumelele isidanga sokuqala waseHunan wohlanga lwaseMiao, wayepapashe amaphepha amabini e-SCI. Ngomhla wesi-2 ku-Epreli 2020, wangeniswa kwisibhedlele sephondo ngenxa yomkhuhlane ophindaphindayo. Uvavanyo lomongo lwamathambo lwamfumanisa ene-acute lymphoblastic leukemia (T-ALL). Emva kwezifundo ezininzi ze-chemotherapy kwisibhedlele sangaphandle, umongo wakhe wamathambo wahlala uphilile. Ngomhla wesi-2 kuNovemba 2020, wafakelwa i-allogeneic hematopoietic stem cell transplant esibhedlele sethu (umzalwana nodade, i-HLA 7/10 match). Emva kokufakelwa, iiseli zafakwa ngempumelelo, kwaye uvavanyo lomongo lwamathambo olulandelayo lwabonisa ukukhululeka okuqhubekayo.

Ngomhla we-16 kweyeSilimela ngo-2021 (iinyanga ezisi-7 emva kokufakelwa isibeleko), uhlolo oluqhelekileyo lwabonisa ukuba i-leukemia yakhe ibuyele umva ngokupheleleyo. I-chemotherapy eyalandelayo ayizange ikwazi ukulawula esi sifo, waza waba nosulelo lwe-pneumonia kunye ne-herpes virus, kunye nezilonda zomlomo ezibuhlungu ezenza kube nzima ukuginya. Wangeniswa kwigumbi lesibini lesebe le-hematology waza wabhaliswa kuvavanyo lweklinikhi lwe-CD7 CAR-T.

Iqela lezonyango libonelele ngonyango olusebenzayo lokulwa nosulelo, ukunciphisa iintlungu, kunye notofelo-gazi oluninzi kunye neeplatelets. Ngenxa yomthwalo omkhulu wethumba (ama-80% okuqhuma kumongo wethambo kunye nama-97% okuqhuma kwigazi elingaphandle), bekungenakwenzeka ukuqokelela iiseli zakhe. Ii-lymphocyte zegazi ezingaphandle ezivela kumxhasi (umnakwabo) zaqokelelwa zaza zathunyelwa kwinkampani ye-biotech yokukhulisa iiseli ze-CAR-T.

Ngomhla we-10 kweyeThupha, ngo-2021, iiseli ze-CD7 CAR-T ezithathwe kwi-donor zaphinda zafakwa. Emva kokufakwa kwakhona, iiseli ze-CAR-T zanda zaya kwi-54.64% egazini elingaphandle, zinomkhuhlane kuphela kwaye azikho iimpawu ezibalulekileyo zokukhululwa kwe-cytokine (CRS) okanye isifo se-graft-versus-host (GVHD). Uvavanyo lomongo wethambo ngomhla we-16 emva kokufakwa kwakhona lwabonisa ukuxolelwa okupheleleyo, kunye neeseli ze-CAR-T ezingama-54.13% kwimongo wethambo. Ngomhla wama-36, umongo wethambo waqhubeka nokubonisa ukuxolelwa okuqhubekayo. Okwangoku, imeko yakhe yengqondo, ubuthongo, kunye nomdla wokutya ilungile, kwaye uyachacha kakuhle.