Te Mate Pūkahukahu Lymphoblastic Koretake (T-ALL)-07

Kua murua katoatia te mate o tētahi kōtiro Miao i muri i te rongoā CAR-T whai muri i te hokinga mai ki te pokanga.

I whakaputa a Amei, he tauira paerua nō Hunan nō te iwi Miao, i ētahi tuhinga SCI e rua. I te 2 o Paenga-whāwhā, 2020, i whakaurua ia ki tētahi hōhipera ā-rohe nā te kirika tonu. I kitea ia he mate toto toto nui (T-ALL) i roto i te whakamātautau hinu wheua. Whai muri i ngā akoranga maha o te chemotherapy i te hōhipera o waho, i noho tonu tōna hinu wheua i roto i te wā e marino ana. I te 2 o Noema, 2020, i tukuna ia ki tētahi whakawhitinga pūtau take hematopoietic allogeneic i tō mātou hōhipera (teina ki te tuahine, HLA 7/10 ōrite). I muri i te whakawhitinga, i angitu te whakaurunga o ngā pūtau, ā, i whakaatuhia e ngā whakamātautau hinu wheua whai muri ko te marino tonu.

I te 16 o Hune, 2021 (7 marama i muri i te whakawhitinga), i kitea i roto i te tirotiro auau kua hoki anō tōna mate toto toto. Kāore i taea e te chemotherapy i muri mai te whakahaere i te mate, ā, ka pāngia ia e te niumōnia me te mate huaketo herpes, me ngā mate pukupuku mamae o te waha e uaua ai te horomi. I whakaurua ia ki te wāhanga tuarua o te tari hematology, ā, i whakaurua ki te whakamātautau haumanu CD7 CAR-T.

I whakaratohia e te tīma hauora he maimoatanga ārai mate kaha, he whakaora mamae, me te tuku toto me ngā whakawhiti pereti toto nui. Nā te nui o te pukupuku (80% ngā pupuhi i roto i te hinu wheua me te 97% ngā pupuhi i roto i te toto ā-taha), kāore i taea te kohi i ana pūtau. I kohia ngā lymphocytes toto ā-taha mai i te kaituku (tōna tungāne) ka tukuna ki tētahi kamupene hangarau koiora mō te ahurea pūtau CAR-T.

I te 10 o Ākuhata, 2021, i whakatōngia anō ngā pūtau CD7 CAR-T i ahu mai i te kaituku. Whai muri i te whakatōngia anō, ka piki ake ngā pūtau CAR-T ki te 54.64% i roto i te toto ā-taha, me te kirika anake, kāore he mate tuku cytokine nui (CRS) me te mate graft-versus-host (GVHD). I whakaatuhia e te whakamātautau hinu wheua i te rā 16 i muri i te whakatōngia anō te murunga katoa, me te 54.13% o ngā pūtau CAR-T i roto i te hinu wheua. I te rā 36, i haere tonu te whakaatu a te hinu wheua i te murunga tonu. I tēnei wā, kei te pai tōna āhua hinengaro, tōna moe, me tōna hiahia kai, ā, kei te ora pai ia.