Khansa ya m'magazi ya Lymphoblastic (T-ALL)-07

Mtsikana wa ku Miao wachira kwathunthu atalandira chithandizo cha CAR-T pambuyo poti wabwereranso ku opaleshoni atangopatsidwanso.

Amei, wophunzira wa ku Hunan wa fuko la Miao, adasindikiza mapepala awiri a SCI. Pa Epulo 2, 2020, adalowetsedwa kuchipatala cha boma chifukwa cha malungo obwerezabwereza. Kuwunika kwa mafupa kunamupeza ndi matenda a acute lymphoblastic leukemia (T-ALL). Pambuyo pa maphunziro angapo a chemotherapy kuchipatala chakunja, mafupa ake adachira. Pa Novembala 2, 2020, adapatsidwa allogeneic hematopoietic hematopoietic stem cell ku chipatala chathu (mchimwene wake ndi mlongo wake, HLA 7/10 match). Pambuyo pomuika, maselowo adalowetsedwa bwino, ndipo mayeso otsatira a mafupa adawonetsa kuti achira.

Pa June 16, 2021 (miyezi 7 atangopatsidwa chiwalo china), kuyezetsa magazi nthawi zonse kunasonyeza kuti khansa yake ya m'magazi inabwereranso. Chithandizo cha chemotherapy chomwe chinatsatira chinalephera kulamulira matendawa, ndipo anayamba matenda a chibayo ndi kachilombo ka herpes, komanso zilonda zopweteka pakamwa zomwe zinapangitsa kuti kumeza kukhale kovuta. Analowetsedwa mu chipinda chachiwiri cha dipatimenti ya hematology ndipo analembetsa mu kafukufuku wa zachipatala wa CD7 CAR-T.

Gulu lachipatala linapereka chithandizo chothandiza polimbana ndi matenda, kuchepetsa ululu, komanso kuikidwa magazi ndi ma platelet ambiri. Chifukwa cha kuchuluka kwa chotupa (80% ya kuphulika kwa mafupa ndi 97% ya kuphulika kwa magazi m'magazi), sizinatheke kusonkhanitsa maselo ake. Ma lymphocyte a m'magazi ochokera kwa woperekayo (mchimwene wake) adasonkhanitsidwa ndikutumizidwa ku kampani ya biotech kuti azitha kupanga maselo a CAR-T.

Pa Ogasiti 10, 2021, maselo a CD7 CAR-T ochokera kwa opereka adabwezeretsedwanso. Pambuyo pobwezeretsanso, maselo a CAR-T adakula kufika pa 54.64% m'magazi ozungulira, ndi malungo okha komanso opanda vuto lalikulu la cytokine release syndrome (CRS) kapena matenda a graft-versus-host (GVHD). Kuwunika kwa mafupa pa tsiku la 16 pambuyo pobwezeretsanso kunawonetsa kuti abwerera kwathunthu, ndi maselo a CAR-T 54.13% m'mafupa. Pa tsiku la 36, ​​mafupa adapitilizabe kusonyeza kuti abwerera bwino. Pakadali pano, malingaliro ake, tulo, ndi chilakolako chake zili bwino, ndipo akuchira bwino.