Leukemia ikabije ya Lymphoblastic (T-ALL)-07

Umukobwa wo muri Miao yakize burundu nyuma yo kuvurwa na CAR-T nyuma yo kongera guterwa inshinge.

Amei, umunyeshuri wo muri kaminuza ya Hunan wo mu bwoko bwa Miao, yari yasohoye inyandiko ebyiri za SCI. Ku ya 2 Mata 2020, yinjiye mu bitaro by’intara kubera umuriro uhoraho. Isuzuma ry’umusemburo w’amagufwa ryagaragaje ko afite kanseri y’amaraso ikabije (T-ALL). Nyuma yo guhabwa imiti myinshi ya chimiothérapie mu bitaro byo hanze, umusemburo w’amagufwa ye wakomeje kugabanuka. Ku ya 2 Ugushyingo 2020, yatewe uturemangingo tw’amaraso two mu maraso two mu bwoko bwa allogeneic mu bitaro byacu (muvandimwe wa mushiki we, HLA 7/10 match). Nyuma yo guterwa, uturemangingo twatewe neza, kandi isuzuma ry’umusemburo w’amagufwa ryagaragaje ko yakize.

Ku ya 16 Kamena 2021 (amezi 7 nyuma yo guterwa inshinge), isuzuma rya buri gihe ryagaragaje ko yongeye kurwara kanseri y'amaraso. Imiti ya kanseri yakurikiyeho ntiyashoboye kugenzura iyi ndwara, maze arwara umusonga na virusi ya herpes, hamwe n'ibisebe byo mu kanwa bibabaza bigatuma bigorana kumira. Yajyanywe mu cyumba cya kabiri cy'ishami ry'ubuvuzi bw'amaraso kandi yandikwa mu igerageza rya CD7 CAR-T.

Itsinda ry’abaganga ryatanze uburyo bwo kuvura indwara zandura, kugabanya ububabare, no guterwa amaraso menshi na platelets. Kubera ko ikibyimba cyari kinini (80% by’ibibyimba mu musokoro w’amagufwa na 97% by’ibibyimba mu maraso yo ku ruhande), ntibyashobotse gukusanya uturemangingo twe. Uturemangingo tw’amaraso two ku ruhande rw’umutanga (murumuna we) twakusanyijwe twoherezwa mu kigo cy’ikoranabuhanga mu bijyanye no kwita ku turemangingo twa CAR-T.

Ku ya 10 Kanama 2021, uturemangingo twa CD7 CAR-T twakuwe mu maraso twasubiwemo. Nyuma yo kongera gushyirwamo, uturemangingo twa CAR-T twariyongereye tugera kuri 54.64% mu maraso yo mu gice cy'imbere, dufite umuriro gusa nta ndwara ikomeye yo gusohora cytokine (CRS) cyangwa indwara ya graft-versus-host (GVHD). Isuzuma ry'umusemburo w'amagufwa ku munsi wa 16 nyuma yo kongera gushyirwamo ryagaragaje ko yakize burundu, aho uturemangingo twa CAR-T twageze kuri 54.13% mu musemburo w'amagufwa. Ku munsi wa 36, ​​umusemburo w'amagufwa wakomeje kugaragaza ko yakize burundu. Ubu, imiterere ye yo mu mutwe, ibitotsi bye, n'ubushake bwo kurya birameze neza, kandi arimo gukira neza.