- Uburyo bwo kuvura
- Ubuhamya
- Neuroblastoma
- Indwara ikomeye
- Ubuhamya
- TILS
- Ubuvuzi bwa Selile za NK
- Myasthenia Gravis (MG)
- Leukemia ikabije ya Lymphoblastic (B-ALL)
- Indwara ya Lupus Erythematosus yo mu mubiri (SLE)
- Leukemia ikabije ya Lymphoblastic (T-ALL)
- Lymphoma itari iya Hodgkin (NHL)
- Myeloma nyinshi (MM)
- Lymphom nini ya B-cell ikwirakwira
- Leukemia ya B-lymphocytic
- Myeloma
Leukemia ikabije ya Lymphoblastic (T-ALL)-03
Ibiranga Urubanza:
- Isuzuma: Leukemia y'urumogi ya T-cell lymphoblastic ikabije
- Itangira n'ibimenyetso: Mata 2020, yagaragayeho isereri, umunaniro, no kuva amaraso mu ruhu. Yasuzumwe afite leukemia y'urumogi rwa T binyuze mu gusuzuma MICM y'umusemburo w'amagufwa.
- Ubuvuzi bw'ibanze: Yahawe ubumuga bwuzuye (CR) nyuma yo guhabwa imiti ya VDCLP, hanyuma ahabwa imiti ya chemotherapy ikaze inshuro ebyiri.
- 19 Nyakanga 2020: Hatanzwe uburyo bwo gutera uturemangingo tw’amaraso twa allogeneic hematopoietic stem cells duturutse ku mugore utanga (HLA 5/10 A donor A). Gahunda yo kuvura indwara yarimo imirasire y’umubiri wose (TBI), cyclophosphamide (CY), na etoposide (VP-16). Uturemangingo tw’amaraso twashyizwemo ku ya 24 Nyakanga, hamwe no kugarura granulocyte ku munsi wa +10 no gushyiramo platelet ku munsi wa +13. Nyuma yaho, hakurikiranwa abarwayi basanzwe hanze.
- Ku ya 25 Gashyantare 2021: Kugaruka k'umusemburo w'amagufwa byagaragaye mu gihe cyo gukurikirana.
- Ubuvuzi: Natangiye kuvura thalidomide mu kanwa.
- 8 Werurwe: Yakiriwe mu bitaro byacu.
- Ishusho y'umusemburo w'amagufwa: 61.5% by'ibisasu.
- Ishyirwa mu byiciro ry'amaraso yo ku nkengero: 15% by'ibisasu.
- Ubushobozi bwo gupima immunophenotype: 35.25% by'uturemangingo tugaragaza CD99, CD5, CD3dim, CD8dim, CD7, cCD3, CD2dim, HLA-ABC, cbcl-2, CD81, CD38, bigaragaza lymphocytes T zitarakura neza.
- Isesengura rya chromosome: 46, XX [9].
- Gene Fusion Gene ya Leukemia: Gene ya fusion ya SIL-TAL1 iri mu maraso; igipimo cy'ingano: SIL-TA.
- Impinduka mu maraso: Negative.
- Isesengura rya Chimerism (nyuma ya HSCT): Uturemangingo dukomoka ku batanga serivisi twagize 45.78%.
- 11 Werurwe: Gukusanya lymphocytes zo mu maraso zikomoka ku maraso kugira ngo haboneke selile za CD7-CART.
- Uburyo bwo kuvura: Vilp (VDS 4mg, IDA 10mg, L-asparaginase 10.000 IU qd x iminsi 4, Dex 9mg q12h x iminsi 9) ihujwe na thalidomide kugira ngo igenzure ikibyimba.
- Werurwe 19: Imiti ya kanseri yo mu bwoko bwa FC (ibicurane 50mg x iminsi 3, CTX 0.4gx iminsi 3).
- 24 Werurwe (mbere yo guterwa): Imiterere y'umusemburo w'amagufwa yagaragaje hyperplasia yo mu rwego rwa V, aho 22% by'ibisasu byaturitse.
- Ingano y'urusobe rw'amagufwa: 29.21% by'uturemangingo (tw'uturemangingo twa nuklei) tugaragaza CD3, CD5, CD7, CD99, tugaragaza igice cya cCD3, bigaragaza uturemangingo twa T tutarakura neza.
- Ingano ya SIL-TAL1 Fusion Gene: 1.913%.
ibisobanuro2
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