Kab mob qog ntshav Lymphoblastic loj heev (T-ALL)-03

Cov Nta ntawm Cov Ntaub Ntawv:

- Kev kuaj mob: Mob ntshav qab zib T-cell lymphoblastic mob hnyav

- Pib thiab Cov tsos mob: Lub Plaub Hlis 2020, tau mob taub hau, qaug zog, thiab los ntshav ntawm daim tawv nqaij. Tau kuaj pom tias muaj mob T-cell lymphoblastic leukemia los ntawm kev kuaj mob pob txha MICM.

- Kev Kho Mob Thaum Pib: Tau txais kev zam txim tag nrho (CR) tom qab VDCLP regimen chemotherapy, ua raws li 2 lub voj voog ntawm kev kho mob chemotherapy hnyav dua.

- Lub Xya Hli 19, 2020: Tau txais kev hloov pauv ntawm cov hlwb hematopoietic los ntawm tus poj niam pub (HLA 5/10 A pub A). Kev kho mob suav nrog kev siv tshuaj tua kab mob rau tag nrho lub cev (TBI), cyclophosphamide (CY), thiab etoposide (VP-16). Cov hlwb peripheral tau txhaj rau lub Xya Hli 24, nrog rau kev rov zoo ntawm granulocyte los ntawm hnub +10 thiab kev cog cov platelet los ntawm hnub +13. Kev saib xyuas tus neeg mob tsis tu ncua tom qab ntawd.

- Lub Ob Hlis 25, 2021: Pom muaj kev rov qab mob ntawm cov pob txha thaum lub sijhawm saib xyuas tom qab.

- Kev Kho Mob: Pib noj tshuaj thalidomide.

- Lub Peb Hlis 8: Tau nkag mus rau hauv peb lub tsev kho mob.

- Cov pob txha pob txha Morphology: 61.5% blasts.

- Kev faib tawm ntawm cov ntshav ncig: 15% blasts.

- Kev ntsuas kab mob immunophenotyping: 35.25% cov hlwb qhia CD99, CD5, CD3dim, CD8dim, CD7, cCD3, CD2dim, HLA-ABC, cbcl-2, CD81, CD38, qhia tias cov T lymphocytes tsis loj hlob zoo.

- Kev Tshuaj Xyuas Chromosome: 46, XX [9].

- Leukemia Fusion Gene: SIL-TAL1 fusion gene zoo; kev ntsuas kom muaj nuj nqis: SIL-TA.

- Kev Hloov Pauv ntawm Cov Qog Ntshav: Tsis Zoo.

- Kev Tshuaj Xyuas Chimerism (tom qab HSCT): Cov hlwb uas tau los ntawm tus neeg pub muaj txog 45.78%.

- Lub Peb Hlis 11: Kev sau cov lymphocytes ntshav peripheral autologous rau CD7-CART cell kab lis kev cai.

- Kev Kho Mob: VILP (VDS 4mg, IDA 10mg, L-asparaginase 10,000 IU txhua hnub x 4 hnub, Dex 9mg txhua 12 teev x 9 hnub) ua ke nrog thalidomide los tswj tus mob qog noj ntshav.

- Lub Peb Hlis 19: Kev kho mob FC regimen chemotherapy (Kab mob khaub thuas 50mg x 3 hnub, CTX 0.4gx 3 hnub).

- Lub Peb Hlis 24 (ua ntej txhaj tshuaj): Cov qauv ntawm cov pob txha hauv lub cev qhia tau tias muaj qib V hyperplasia, nrog rau 22% blasts.

- Kev ntsuas cov hlwb pob txha ntws: 29.21% cov hlwb (ntawm cov hlwb nucleated) qhia tawm CD3, CD5, CD7, CD99, qhia tawm ib feem ntawm cCD3, qhia txog cov hlwb T tsis loj hlob zoo.

- Kev sib xyaw ua ke ntawm SIL-TAL1 Gene: 1.913%.