Leukemia e matla ea Lymphoblastic (T-ALL)-03

Likarolo tsa Nyeoe:

- Tlhahlobo: Leukemia e matla ea lisele tsa T tsa lymphoblastic

- Ho Qala le Matšoao: Mmesa 2020, e ne e e-na le ho tsekela, mokhathala le lintlha tse tsoang mali letlalong. E fumanoe e na le leukemia e matla ea T-cell lymphoblastic ka tlhahlobo ea MICM ea moko oa masapo.

- Kalafo ea Pele: Ho fihletsoe pholiso e felletseng (CR) kamora kalafo ea chemotherapy ea VDCLP, e lateloa ke lipotoloho tse peli tsa chemotherapy e matlafalitsoeng.

- Phupu 19, 2020: Ho amohetsoe phetisetso ea lisele tsa stem tsa hematopoietic tse tsoang ho mofani oa mosali (HLA 5/10 A mofani A). Mokhoa oa ho lokisa o ne o kenyelletsa mahlaseli a 'mele kaofela (TBI), cyclophosphamide (CY), le etoposide (VP-16). Lisele tsa stem tsa peripheral li ile tsa kenngoa ka la 24 Phupu, ka ho hlaphoheloa ha granulocyte ka letsatsi la +10 le ho kenngoa ha platelet ka letsatsi la +13. Ho latela bakuli ba kantle khafetsa ka mor'a moo.

- La 25 Hlakola 2021: Ho kgutlela morao ha moko wa masapo ho ile ha fumanwa nakong ya tlhahlobo.

- Kalafo: Ke qalile kalafo ea thalidomide ka molomo.

- La 8 Tlhakubele: Ke amohetsoe sepetlele sa rona.

- Sebopeho sa 'Marotholi a Masapo: 61.5% ea ho phatloha.

- Sehlopha sa Mali a ka Pel'a ...

- Immunophenotyping: 35.25% ea lisele tse hlahisang CD99, CD5, CD3dim, CD8dim, CD7, cCD3, CD2dim, HLA-ABC, cbcl-2, CD81, CD38, tse bontšang li-lymphocyte tsa T tse sa holang tse kotsi.

- Tlhahlobo ea Chromosome: 46, XX [9].

- Leukemia Fusion Gene: Jén fusion gene ya SIL-TAL1 e ntle; tekanyo ya bongata: SIL-TA.

- Phetoho ea Hlahala ea Mali: Ha e mpe.

- Tlhahlobo ea Chimerism (kamora HSCT): Lisele tse nkiloeng ho bafani li ne li ikarabella bakeng sa 45.78%.

- La 11 Tlhakubele: Pokello ea li-lymphocyte tsa mali tse ka hare ho 'mele bakeng sa setso sa lisele tsa CD7-CART.

- Kalafo: Mokhoa oa VILP (VDS 4mg, IDA 10mg, L-asparaginase 10,000 IU qd x matsatsi a 4, Dex 9mg q12h x matsatsi a 9) o kopantsoeng le thalidomide ho laola hlahala.

- La 19 Tlhakubele: Phekolo ea chemotherapy ea regimen ea FC (Flu 50mg x matsatsi a 3, CTX 0.4gx matsatsi a 3).

- La 24 Tlhakubele (pele ho kenngoa): Sebopeho sa moko oa masapo se bontšitse hyperplasia ea sehlopha sa V, ka 22% ea ho phatloha.

- Bone Morrow Flow Cytometry: 29.21% ea lisele (tsa lisele tse nang le nucleotide) tse hlahisang CD3, CD5, CD7, CD99, tse hlahisang cCD3 ka karolo e itseng, tse bontšang lisele tsa T tse sa holang tse kotsi.

- Phapang ea liphatsa tsa lefutso tsa SIL-TAL1 tse nang le bongata: 1.913%.