Leukemia-da Lymphoblastic ee daran (T-ALL)-03

Astaamaha Kiiska:

- Baadhista: Cudurka 'pneum T-cell lymphoblastic leukemia' ee daran

- Bilawga iyo Calaamadaha: Abriil 2020, oo lagu soo bandhigay wareer, daal, iyo dhibco dhiig ah oo maqaarka ah. Waxaa lagu ogaaday cudurka 'T-cell lymphoblastic leukemia' iyadoo la adeegsanayo baaritaanka MICM ee dhuuxa lafta.

- Daaweynta Bilowga ah: Waxaa la gaaray cafis dhammaystiran (CR) ka dib daaweynta kiimoterabiga ee VDCLP, oo ay ku xigto 2 wareeg oo kiimoterabiga ah oo la xoojiyay.

- Luulyo 19, 2020: Waxaa la siiyay tallaal unugyada asliga ah ee dhiigga oo allogeneic ah oo laga helay deeq-bixiye dumar ah (HLA 5/10 A deeq-bixiye A). Nidaamka qaboojinta waxaa ka mid ahaa shucaaca jirka oo dhan (TBI), cyclophosphamide (CY), iyo etoposide (VP-16). Unugyada asliga ah ee ku wareegsan ayaa la geliyay Luulyo 24, iyadoo soo kabashada granulocyte-ka ay ka soo kabato +10 iyo qorista platelet-ka maalinta +13. Dabagal joogto ah oo bukaan-socod ah ka dib.

- Febraayo 25, 2021: Dib u soo noqoshada dhuuxa lafta ayaa la ogaaday intii lagu jiray dabagalka.

- Daawaynta: Bilaabay daawaynta thalidomide ee afka laga qaato.

- Maarso 8: Isbitaalkayaga ayaa la dhigay.

- Qaab-dhismeedka Dhuuxa Lafaha: 61.5% qaraxyo.

- Kala soocidda Dhiigga ee Dusha sare: 15% qaraxyo.

- Tijaabinta Difaaca Jirka: 35.25% unugyo muujinaya CD99, CD5, CD3dim, CD8dim, CD7, cCD3, CD2dim, HLA-ABC, cbcl-2, CD81, CD38, oo muujinaya unugyada T ee aan qaan gaarin ee halista ah.

- Falanqaynta Kroomosmka: 46, XX [9].

- Hiddo-sidayaasha Isku-dhafka Leukemia: Hiddo-sidayaasha isku-dhafka SIL-TAL1 ee togan; cabbirka tirada: SIL-TA.

- Isbeddelka Burada Dhiigga: Taban.

- Falanqaynta Chimerism (ka dib HSCT): Unugyada ka soo jeeda deeq-bixiyayaashu waxay ahaayeen 45.78%.

- Maarso 11: Ururinta unugyada dhiigga ee isku-dhafan ee iswada si loogu sameeyo unugyada CD7-CART.

- Daawaynta: VILP (VDS 4mg, IDA 10mg, L-asparaginase 10,000 IU qd x 4 maalmood, Dex 9mg q12h x 9 maalmood) oo lagu daray thalidomide si loo xakameeyo burooyinka.

- Maarso 19: Kiimikada daaweynta FC (Hargabka 50mg x 3 maalmood, CTX 0.4gx 3 maalmood).

- Maarso 24 (kahor gelinta): Qaab-dhismeedka dhuuxa lafta ayaa muujiyay heerka V hyperplasia, iyadoo 22% qaraxyo ay dhaceen.

- Cytometry Socodka Dhuuxa Lafaha: 29.21% unugyo (unugyada nuclear-ka) oo muujiya CD3, CD5, CD7, CD99, oo qayb ahaan muujiya cCD3, taasoo muujinaysa unugyada T ee aan qaan-gaarin ee halista ah.

- Hiddo-sidayaasha Isku-dhafka SIL-TAL1 ee tirada leh: 1.913%.