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Pawg Neeg Mob
Cov Ntaub Ntawv Tshwj Xeeb
Kab mob Lymphoma B-cell loj (DLBCL)-04

Kab mob Lymphoma B-cell loj (DLBCL)-04
Kev Kho Mob CAR-T rau Myasthenia Gravis (MG)

Kev Kho Mob CAR-T rau Myasthenia Gravis (MG)
Kev Kho Mob Cancer: Kev Kho Mob Cancer Siab Tshaj Plaws

Kev Kho Mob Cancer: Kev Kho Mob Cancer Siab Tshaj Plaws
Ib tug tub hluas uas muaj mob leukemia lymphoblastic loj heev

Ib tug tub hluas uas muaj mob leukemia lymphoblastic loj heev
Kev Kov Yeej Diffuse Large B-Cell Lymphoma nrog Bioocus Dual CAR-T Therapy

Kev Kov Yeej Diffuse Large B-Cell Lymphoma nrog Bioocus Dual CAR-T Therapy
Kev Kho Mob Hepatocellular Carcinoma nrog Bioocus GPC3 CAR-T Therapy

Kev Kho Mob Hepatocellular Carcinoma nrog Bioocus GPC3 CAR-T Therapy
Cov Lus Teb Zoo Kawg Nkaus Hauv Refractory Multiple Myeloma Tom Qab CAR-T Cell Therapy

Cov Lus Teb Zoo Kawg Nkaus Hauv Refractory Multiple Myeloma Tom Qab CAR-T Cell Therapy
Madhavan Txoj Kev Yeej: Kev Yeej Kab Mob Glioma Hauv Hlwb Nrog Bioocus B7H3 CAR-T Therapy

Madhavan Txoj Kev Yeej: Kev Yeej Kab Mob Glioma Hauv Hlwb Nrog Bioocus B7H3 CAR-T Therapy
Ib tug tub hluas uas muaj zog los ntawm Russia tawm tsam neuroblastoma

Ib tug tub hluas uas muaj zog los ntawm Russia tawm tsam neuroblastoma
Ib tug txiv neej uas mob siab rau los ntawm Is Nrias teb tawm tsam mob qog noj ntshav hauv plab

Ib tug txiv neej uas mob siab rau los ntawm Is Nrias teb tawm tsam mob qog noj ntshav hauv plab
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Kab mob qog ntshav Lymphoblastic loj heev (T-ALL)-05

Tus neeg mob: Tsis qhia npe

Txiv neej thiab poj niamTxiv neej

Hnub nyoog: muaj 15 xyoo

Haiv neeg: Suav

Kev kuaj mobKab mob qog ntshav Lymphoblastic mob hnyav (T-ALL)

    Tiv tauj peb

    Kev zam txim ntawm tus neeg mob T-ALL uas rov qab mob uas muaj kab mob ntshav qab zib hauv lub paj hlwb tom qab CAR-T Therapy


    Cov ntaub ntawv no cuam tshuam txog ib tug tub hluas hnub nyoog 16 xyoo los ntawm Northeast China, uas nws txoj kev taug kev nrog mob leukemia tau muaj ntau yam kev cov nyom txij li thaum nws kuaj pom tias muaj mob ntau tshaj ib xyoos dhau los.


    Thaum Lub Kaum Ib Hlis 8, 2020, Dawei (lub npe cuav) tau mus rau tsev kho mob hauv zos vim nws lub ntsej muag tawv, pob khaus, thiab lub qhov ncauj nkhaus. Nws tau kuaj pom tias muaj "acute lymphoblastic leukemia (T-cell type)." Tom qab ib chav kawm induction chemotherapy, MRD (minimal residual disease) tsis muaj, tom qab ntawd yog chemotherapy tas li. Thaum lub sijhawm no, kev txhaj tshuaj pob txha, kev txhaj tshuaj lumbar, thiab kev txhaj tshuaj intrathecal tsis pom muaj qhov txawv txav.


    Thaum Lub Tsib Hlis 6, 2021, tau ua ib qho kev tho qhov ntawm lub duav nrog kev txhaj tshuaj rau hauv lub plab mog, thiab kev tshuaj xyuas cov kua dej cerebrospinal (CSF) tau lees paub tias "mob leukemia ntawm lub paj hlwb hauv nruab nrab." Qhov no tau ua raws li ob chav kawm ntawm kev kho mob chemotherapy. Thaum Lub Rau Hli 1, kev tho qhov ntawm lub duav nrog kev tshuaj xyuas CSF tau pom cov hlwb tsis tau loj hlob. Peb qhov kev tho qhov ntawm lub duav ntxiv nrog kev txhaj tshuaj rau hauv lub plab mog, nrog rau qhov kev kuaj CSF zaum kawg tsis qhia cov hlwb qog.


    Thaum Lub Xya Hli 7, Dawei tau muaj teeb meem pom kev hauv nws lub qhov muag sab xis, tsuas pom lub teeb xwb. Tom qab ib qho kev kho mob chemotherapy hnyav dua, nws lub qhov muag sab xis rov qab zoo li qub.


    Thaum Lub Yim Hli 5, nws lub qhov muag sab xis pom kev tsis zoo dua, ua rau nws dig muag tag, thiab nws lub qhov muag sab laug tsis meej. Txij Lub Yim Hli 10 txog 13, nws tau txais kev kho mob hluav taws xob tag nrho lub hlwb thiab tus txha caj qaum (TBI), uas ua rau nws lub qhov muag sab laug pom kev zoo dua, tab sis lub qhov muag sab xis tseem dig muag. Thaum Lub Yim Hli 16, kev kuaj MRI ntawm lub hlwb qhia tau tias cov hlab ntsha sab xis thiab chiasm tuab zuj zus, thiab pom tias muaj kev txhim kho me ntsis. Tsis pom muaj cov cim qhia tsis zoo lossis kev txhim kho hauv cov hlwb parenchyma.


    Lub sijhawm no, tsev neeg tau npaj rau kev hloov pob txha, tos tsuas yog ib lub txaj hauv chav hloov pob txha xwb. Hmoov tsis zoo, kev kuaj mob ua ntej hloov pob txha ib txwm qhia txog teeb meem uas ua rau kev hloov pob txha tsis yooj yim sua.

    2219

    Thaum Lub Yim Hli 30, tau ua ib qho kev tho qhov pob txha, qhia txog cov pob txha MRD nrog cov T lymphocytes tsis paub tab uas suav txog 61.1%. Kuj tau ua ib qho kev tho qhov lumbar nrog kev txhaj tshuaj rau hauv lub qhov quav, qhia txog CSF MRD nrog tag nrho 127 lub hlwb, uas cov T lymphocytes tsis paub tab uas muaj 35.4%, qhia txog kev rov qab mob leukemia tag nrho.

    Thaum Lub Yim Hli 31, 2021, Dawei thiab nws tsev neeg tau tuaj txog ntawm peb lub chaw CGT. Cov kev kuaj ntshav nkag mus rau hauv tsev kho mob qhia tau tias: WBC 132.91 × 10^9/L; qhov sib txawv ntawm cov ntshav peripheral (morphology): 76.0% blasts. Kev kho mob induction chemotherapy tau muab rau ib chav kawm.

    Tom qab saib xyuas Dawei txoj kev kho mob yav dhau los, nws pom tseeb tias nws tus T-ALL tsis kho tau/rov qab mob dua thiab cov qog nqaij hlav tau nkag mus rau hauv lub hlwb, cuam tshuam rau cov hlab ntsha pom. Pawg neeg kho mob tau txiav txim siab tias Dawei ua tau raws li cov qauv rau kev sau npe rau hauv CD7 CAR-T kev sim tshuaj.

    Thaum lub Cuaj Hlis 18, lwm qhov kev kuaj mob tau ua tiav: qhov sib txawv ntawm cov ntshav ntawm cov hlab ntsha (morphology) qhia tau tias muaj 11.0% blasts. Cov ntshav lymphocytes ntawm cov hlab ntsha tau sau rau CD7 CAR-T cell kab lis kev cai tib hnub, thiab cov txheej txheem tau mus zoo. Tom qab sau, chemotherapy tau muab los npaj rau CD7 CAR-T cell immunotherapy.

    Thaum lub sijhawm kho mob chemotherapy, cov hlwb qog tau nthuav dav sai heev. Thaum Lub Kaum Hli 6, qhov sib txawv ntawm cov ntshav ntawm cov hlab ntsha (morphology) tau qhia txog 54.0% blasts, thiab kev kho mob chemotherapy tau hloov kho kom txo tau qhov hnyav ntawm cov qog. Thaum Lub Kaum Hli 8, kev tshuaj xyuas cov hlwb pob txha morphology tau qhia txog 30.50% blasts; MRD qhia tias 17.66% ntawm cov hlwb yog cov T lymphocytes tsis loj hlob.

    Thaum Lub Kaum Hli Ntuj hnub tim 9, cov qe ntshav CD7 CAR-T tau rov qab txhaj dua. Tom qab txhaj dua, tus neeg mob rov qab kub taub hau thiab mob pos hniav. Txawm hais tias tau kho mob tiv thaiv kab mob zoo dua, qhov kub taub hau tsis tau tswj tau zoo, txawm hais tias qhov mob pos hniav maj mam ploj mus.

    Tom qab muab tshuaj rov qab rau hnub 11, cov ntshav tawm hauv cov hlab ntsha tau nce mus txog 54%; rau hnub 12, kev kuaj ntshav pom tias cov qe ntshav dawb nce mus txog 16 × 10 ^ 9 / L. Rau hnub 14 tom qab muab tshuaj rov qab rau hnub, tus neeg mob tau muaj CRS hnyav, suav nrog kev puas tsuaj rau lub plawv, lub siab thiab lub raum ua haujlwm tsis zoo, hypoxemia, ntshav hauv plab hnyuv qis, thiab qaug dab peg. Kev kho mob hnyav thiab kev txhawb nqa, nrog rau kev pauv plasma, maj mam txhim kho kev ua haujlwm ntawm cov kab mob cuam tshuam, ua kom tus neeg mob lub cim tseem ceeb ruaj khov.

    Thaum Lub Kaum Hli Ntuj hnub tim 27, tus neeg mob muaj zog ntawm cov leeg nqaij hauv ob sab ceg qis yog 0. Thaum Lub Kaum Hli Ntuj hnub tim 29 (21 hnub tom qab rov txhaj tshuaj dua), qhov kev kuaj MRD ntawm cov pob txha tsis pom zoo.

    Thaum lub sijhawm uas nws zoo tag nrho lawm, Dawei tau ua kom nws ob txhais ceg ua haujlwm tau zoo dua nrog kev pab los ntawm cov kws saib mob thiab tsev neeg, maj mam rov qab muaj zog cov leeg nqaij mus txog 5 qib. Thaum Lub Kaum Ib Hlis 22, nws tau raug xa mus rau chav hloov hlwb kom npaj rau kev hloov hlwb allogeneic hematopoietic stem cell.

    piav qhia2

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