Kab mob qog ntshav Lymphoblastic loj heev (T-ALL)-06

Ib tug menyuam yaus hnub nyoog 2 xyoos uas muaj T-ALL tau zoo tom qab kev kho mob CAR-T tom qab ntau tshaj kaum zaug kev kho mob chemotherapy.

Tus me nyuam Xiaohong uas muaj ob xyoos los ntawm Zhejiang tau kuaj pom tias muaj mob leukemia lub caij ntuj sov dhau los. Tom qab ntau tshaj ib xyoos ntawm kev kho mob, cov txheej txheem flow cytometry pom tias muaj kev rov qab mob dua, ua rau tsev neeg mus nrhiav kev kho mob CAR-T immunotherapy ntawm BIOOCUS Medical Group.

Thaum Lub Yim Hli 9, 2020, Xiaohong tau raug xa mus rau tsev kho mob menyuam yaus hauv zos vim "mob kub taub hau peb hnub." Kev kuaj mob pob txha MICM tau kuaj pom tias muaj mob leukemia lymphoblastic (T-ALL). Tom qab ib chav kawm chemotherapy, cov qauv pob txha qhia tau tias nws zoo tag nrho, thiab flow cytometry tsis pom muaj cov hlwb tsis loj hlob. Kev kho mob chemotherapy ntau dua 11 chav kawm tom qab ntawd ua rau cov pob txha zoo tag nrho.

Thaum lub Cuaj Hlis 3, 2021, kev phais pob txha tom qab tau qhia tias cov morphology tau zoo tag nrho, tab sis cov flow cytometry qhia tau tias muaj 1.85% cov hlwb tsis loj hlob. Xav tau kev kho mob ntxiv, Xiaohong tau raug xa mus rau peb lub chaw CGT thaum lub Cuaj Hlis 24. Thaum nkag mus, cov morphology ntawm pob txha tseem zoo tag nrho, tab sis immunophenotyping qhia tau tias muaj 0.10% cov T lymphocytes tsis loj hlob.

Xav txog Xiaohong lub hnub nyoog tseem hluas thiab tus kab mob no tseem muaj sia nyob txawm tias muaj ntau tshaj kaum zaug ntawm kev kho mob chemotherapy, pab pawg kho mob hauv chav thib ob ntawm chav kho mob ntshav tau txiav txim siab tias Xiaohong tuaj yeem sau npe rau hauv CD7 CAR-T kev sim tshuaj.

Thaum lub Cuaj Hlis 30, 2021, cov qe ntshav dawb tau raug sau los ua kab mob CAR-T. Thaum Lub Kaum Hli 10, Xiaohong tau txais kev kho mob chemotherapy FC. Thaum Lub Kaum Hli 13, kev txiav cov pob txha hauv lub cev qhia tias muaj tsawg dua 5% ntawm cov qe ntshav dawb hauv cov qauv, thiab cov cytometry qhia tias muaj 0.37% ntawm cov qe ntshav dawb tsis loj hlob. Thaum Lub Kaum Hli 15, cov qe ntshav dawb CD7 CAR-T tau raug rov ua dua.

Thaum Lub Ib Hlis Ntuj hnub tim 3 (20 hnub tom qab rov ua kom cov ntshav rov qab los), qhov kev txiav cov pob txha tau qhia tias nws zoo tag nrho hauv cov qauv, tsis muaj cov hlwb phem uas tsis tau loj hlob los ntawm kev ntsuas cov ntshav ntws. Xiaohong tus mob tau ruaj khov txij li thaum ntawd los, thiab nws tau raug xa mus rau chav hloov hlwb kom npaj rau kev hloov hlwb allogeneic hematopoietic stem cell.

Xiaohong muaj hnub nyoog tsawg dua ib xyoos thaum nws mob thiab raug kev txom nyem ntau tshaj ib xyoos ntawm kev kho mob tshuaj. Kev sib txuas ua tiav mus rau kev hloov pauv tom qab kev kho mob CD7 CAR-T tau muab riam phom muaj zog los kov yeej tus kab mob tag nrho.