I-Acute Lymphoblastic Leukemia (T-ALL)-06

Isigulana sabantwana esineminyaka emi-2 ubudala esine-T-ALL sifumana ukuphumla emva konyango lwe-CAR-T emva kokufumana i-chemotherapy enzulu izihlandlo ezingaphezu kweshumi.

UXiaohong oneminyaka emibini ubudala waseZhejiang wafunyaniswa ene-leukemia ehlotyeni elidlulileyo. Emva konyango olungaphezu konyaka, i-flow cytometry yafumanisa ukuba isifo siphinde sabuyela esiqhelweni, nto leyo eyakhokelela ekubeni usapho lufune unyango lwe-CAR-T immunotherapy kwi-BIOOCUS Medical Group.

Ngomhla wesi-9 kweyeThupha, ngowama-2020, uXiaohong wangeniswa kwisibhedlele sabantwana sasekuhlaleni ngenxa "yomkhuhlane weentsuku ezintathu." Uvavanyo lwe-MICM yomongo lwafumanisa ukuba une-acute lymphoblastic leukemia (T-ALL). Emva kwekhosi enye ye-chemotherapy, i-bone marrow morphology yabonisa ukuxolelwa okupheleleyo, kwaye i-flow cytometry ayizange ifumane iiseli ezinobungozi ezingavuthwanga. I-chemotherapy enzulu eyalandelayo kwiikhosi ezili-11 yagcina ukuxolelwa okupheleleyo komongo wethambo.

Ngomhla wesi-3 kuSeptemba 2021, ukugqobhozwa komnkantsha wethambo okulandelayo kwabonisa ukuxolelwa ngokupheleleyo kwimo yeseli, kodwa i-flow cytometry yabonisa iiseli ezingavuthwanga eziyi-1.85%. Efuna unyango olongezelelweyo, uXiaohong wangeniswa kwiziko lethu le-CGT ngomhla wama-24 kuSeptemba. Emva kokungeniswa, imo yemnkantsha wethambo yayisekwimo yemnkantsha epheleleyo, kodwa i-immunophenotyping yabonisa ukuba ii-lymphocytes ze-T ezingavuthwanga ziyi-0.10%.

Ngenxa yokuba uXiaohong wayesemncinci kwaye esi sifo siqhubeke ixesha elide nangona wayefumana unyango oluqatha lwe-chemotherapy, iqela lezonyango kwicandelo lesibini le-hematology lagqiba kwelokuba uXiaohong angabhalisa kuvavanyo lweklinikhi lwe-CD7 CAR-T.

Ngomhla wama-30 kuSeptemba, ngo-2021, kwaqokelelwa iiseli zegazi ezingaphandle ukuze kukhuliswe iiseli ze-CAR-T. Ngomhla we-10 kuOkthobha, uXiaohong wafumana i-FC regimen chemotherapy. Ngomhla we-13 kuOkthobha, ukubhobozwa kwethambo lomongo kwabonisa ukuqhuma okungaphantsi kwe-5% kwi-morphology, kwaye i-flow cytometry yabonisa iiseli ze-T ezingekavuthwa ezingama-0.37%. Ngomhla we-15 kuOkthobha, iiseli ze-CD7 CAR-T zaphinda zafakwa.

Ngomhla wesi-3 kweyoMqungu (iintsuku ezingama-20 emva kokufakelwa kwakhona), ukubhobozwa komongo wethambo kwabonisa ukuxolelwa ngokupheleleyo kwimo yeseli, kungekho ziseli zingavuthwanga ezifunyenweyo yi-flow cytometry. Imeko kaXiaohong izinzile ukususela ngoko, kwaye udluliselwe kwicandelo lokufakelwa ukuze alungiselele ukufakelwa kweseli ye-hematopoietic stem.

UXiaohong wayengaphantsi konyaka ubudala xa wagula waza wanyamezela unyango lwamayeza unyaka wonke. Ukuphumelela ekutshintsheni iseli emva konyango lwe-CD7 CAR-T kuye kwanika isixhobo esinamandla sokuphelisa ngokupheleleyo esi sifo.