Leukemia ikabije ya Lymphoblastic (T-ALL)-06

Umurwayi w'umwana w'imyaka 2 ufite T-ALL yagabanutse nyuma yo kuvurwa na CAR-T nyuma yo gukorerwa imiti igabanya ubukana inshuro zirenga icumi.

Xiaohong w'imyaka ibiri ukomoka i Zhejiang yasanzwemo kanseri y'amaraso mu mpeshyi ishize. Nyuma y'igihe kirenga umwaka avurwa, ubuvuzi bwa "flow cytometry" bwagaragaje ko yongeye kurwara indwara yo mu bwonko, bituma umuryango ujya gushaka ubuvuzi bwa CAR-T muri BIOOCUS Medical Group.

Ku ya 9 Kanama 2020, Xiaohong yajyanywe mu bitaro by’abana byo muri ako gace kubera "umuriro w'iminsi itatu." Isuzuma rya MICM ry’umusemburo w’amagufwa ryagaragaje ko habayeho kanseri y’imitsi ikabije (T-ALL). Nyuma yo guhabwa imiti igabanya ubukana bwa kanseri, imiterere y’umusemburo w’amagufwa yagaragaje ko habayeho ubukana bwuzuye, kandi imiterere y’imitsi yanduye yasanze nta tunyangingo twanduye twanduye. Imiti igabanya ubukana bwa kanseri yakurikiyeho mu masomo 11 yakomeje koroherwa burundu mu musemburo w’amagufwa.

Ku ya 3 Nzeri 2021, gukubitwa kw'umusemburo w'amagufwa byakurikiranye byagaragaje ko uturemangingo tw’umubiri twagize ikibazo cy’uko ...

Bitewe n'ubuto bwa Xiaohong n'uko indwara ikomeje nubwo yamaze inshuro zirenga icumi ahabwa imiti igabanya ubukana, itsinda ry'abaganga bo mu cyumba cya kabiri cy'ishami ry'ubuvuzi bw'amaraso ryafashe icyemezo cy'uko Xiaohong ashobora kwiyandikisha mu igerageza rya CD7 CAR-T.

Ku ya 30 Nzeri 2021, hakusanyijwe uturemangingo tw’amaraso two mu miyoboro y’amaraso kugira ngo haboneke ubuvuzi bw’uturemangingo twa CAR-T. Ku ya 10 Ukwakira, Xiaohong yahawe imiti ya chimiotherapie ya FC. Ku ya 13 Ukwakira, gupfunyika kw’umusemburo w’amagufwa byagaragaje ko hari ibisasu biri munsi ya 5% mu miterere y’uturemangingo, naho flow cytometry igaragaza ko hari uturemangingo twa T tutarakura turi 0.37%. Ku ya 15 Ukwakira, uturemangingo twa CD7 CAR-T twongeye gushyirwamo.

Ku itariki ya 3 Mutarama (iminsi 20 nyuma yo kongera gushyirwamo), gutobora umwongo w'amagufwa byagaragaje ko byorohewe burundu mu miterere y'umubiri, nta turemangingo twanduye twagaragaye hakoreshejwe uburyo bwo kuvura indwara. Imiterere ya Xiaohong yarahindutse, maze yimurirwa mu ishami rishinzwe gutera utwo turemangingo kugira ngo yitegure gutera utwo turemangingo tw'amaraso two mu bwoko bwa allogeneic hematopoietic.

Xiaohong yari atarageza ku mwaka umwe ubwo yarwaraga kandi yamaze umwaka avurwa n'imiti. Kuba yarabashije gutera inshinge nyuma yo kuvurwa na CD7 CAR-T byamuhaye intwaro ikomeye yo gutsinda burundu iyi ndwara.