Te Mate Pūkahukahu Lymphoblastic Whakapeka (T-ALL)-06

Kua murua te mate o tētahi tamaiti e 2-tau te pakeke me te T-ALL i muri i te rongoā CAR-T whai muri i te neke atu i te tekau ngā rauna o te chemotherapy kaha.

I te raumati kua taha ake nei, i kitea he mate toto i a Xiaohong, e rua tau te pakeke, nō Zhejiang. I muri i te neke atu i te tau o te maimoatanga, i kitea e te flow cytometry he hokinga mai o te mate, ā, i ārahi te whānau ki te rapu i te CAR-T immunotherapy i BIOOCUS Medical Group.

I te 9 o Ākuhata, 2020, i whakaurua a Xiaohong ki tētahi hōhipera tamariki o te rohe nā te "kirika e toru ngā rā." I kitea i roto i te whakamātautau MICM o te hinu wheua te mate toto toto nui (T-ALL). Whai muri i te kotahi akoranga o te chemotherapy, i whakaatuhia e te āhua o te hinu wheua te murunga katoa, ā, kāore i kitea e te flow cytometry ngā pūtau kino kāore anō kia pakari. Nā te chemotherapy kaha i muri mai i roto i ngā akoranga 11 i pupuri tonu te murunga katoa o te hinu wheua.

I te 3 o Hepetema, 2021, i whakaatuhia e te pokanga wheua whai muri i te murunga katoa o te āhua, engari i whakaatuhia e te flow cytometry he 1.85% ngā pūtau kino kāore anō kia pakeke. I te rapu maimoatanga anō, i whakaurua a Xiaohong ki tā mātou pokapū CGT i te 24 o Hepetema. I te whakaurunga, kei te murunga katoa tonu te āhua o te wheua, engari i whakaatuhia e te immunophenotyping he 0.10% ngā pūtau kino kāore anō kia pakeke o te T lymphocytes.

I te whakaaro ki te taitamarikitanga o Xiaohong me te mau tonu o te mate ahakoa neke atu i te tekau ngā rauna o te rongoā chemotherapy kaha, i whakatau te tīma hauora o te wāhanga tuarua o te tari hematology kia whakauru atu a Xiaohong ki te whakamātautau haumanu CD7 CAR-T.

I te 30 o Hepetema, 2021, i kohia ngā pūtau toto ā-taha mō te ahurea pūtau CAR-T. I te 10 o Oketopa, i whiwhi a Xiaohong i te rongoā chemotherapy FC. I te 13 o Oketopa, i whakaatuhia e te pokanga wheua he iti iho i te 5% ngā pahūtanga i roto i te āhua, ā, i whakaatuhia e te flow cytometry he 0.37% ngā pūtau T kino kāore anō kia pakari. I te 15 o Oketopa, i whakatōkia anō ngā pūtau CD7 CAR-T.

I te 3 o Hānuere (20 ngā rā i muri i te whakaurunga anō), i kitea te āhua o te wheua kua marino katoa i te werohanga, kāore he pūtau kino kāore anō kia pakari i kitea e te flow cytometry. Kua tau te āhua o Xiaohong mai i taua wā, ā, kua whakawhitia ia ki te tari whakawhitinga hei whakarite mō te whakawhitinga pūtau take hematopoietic allogeneic.

Kāore anō kia kotahi tau te pakeke o Xiaohong i te wā i pāngia ai ia e te mate, ā, neke atu i te tau te roa o te maimoatanga rongoā. Nā te angitu o te whakawhiti ira ki te whakawhitinga ira i muri i te rongoā CD7 CAR-T kua whakaratohia he patu kaha hei hinga rawa i te mate.