I-Acute Lymphoblastic Leukemia (T-ALL)-06

Isiguli sezingane esineminyaka emibili ubudala esine-T-ALL sithola ukuphulukiswa ngemva kokwelashwa nge-CAR-T ngemuva kokwelashwa ngamakhemikhali anamandla angaphezu kweshumi.

UXiaohong oneminyaka emibili ubudala waseZhejiang watholakala enesifo somdlavuza wegazi ehlobo eledlule. Ngemva kokwelashwa isikhathi esingaphezu konyaka, i-flow cytometry yathola ukuthi isifo siphinde sibuye, okwaholela umndeni ekufuneni i-CAR-T immunotherapy kwa-BIOOCUS Medical Group.

Ngo-Agasti 9, 2020, uXiaohong wangeniswa esibhedlela sezingane sendawo ngenxa "yomkhuhlane wezinsuku ezintathu." Ukuhlolwa kwe-MICM yomnkantsha kwathola ukuthi i-acute lymphoblastic leukemia (T-ALL). Ngemva kwenkambo eyodwa yokwelashwa ngamakhemikhali, i-bone marrow morphology yabonisa ukuphulukiswa okuphelele, kanti i-flow cytometry ayizange ithole amangqamuzana amabi angakavuthwa. I-chemotherapy enamandla eyalandela ngaphezu kwezifundo ezingu-11 yagcina ukuphulukiswa okuphelele komnkantsha.

NgoSepthemba 3, 2021, ukubhobozwa komnkantsha okulandelayo kwabonisa ukuxolelwa okuphelele ku-morphology, kodwa i-flow cytometry yaveza amangqamuzana angakavuthwa angu-1.85%. Efuna ukwelashwa okwengeziwe, uXiaohong wangeniswa esikhungweni sethu se-CGT ngoSepthemba 24. Lapho engeniswa, i-morphology yomnkantsha yayisesekuxolelwe okuphelele, kodwa i-immunophenotyping yabonisa ukuthi ama-lymphocyte e-T angakavuthwa angu-0.10%.

Uma sibheka iminyaka kaXiaohong esemncane kanye nokuqhubeka kwalesi sifo naphezu kokwelashwa ngamakhemikhali okunamandla okungaphezu kweshumi, ithimba lezokwelapha egunjini lesibili lomnyango we-hematology lanquma ukuthi uXiaohong angabhalisa esivivinyweni somtholampilo se-CD7 CAR-T.

NgoSepthemba 30, 2021, kwaqoqwa amaseli egazi angaphandle ukuze kukhiqizwe isiko lamaseli e-CAR-T. Ngo-Okthoba 10, uXiaohong wathola i-FC regimen chemotherapy. Ngo-Okthoba 13, ukubhobozwa komnkantsha kwabonisa ukuqhuma okungaphansi kuka-5% ku-morphology, kanti i-flow cytometry yabonisa amaseli e-T angakavuthwa angama-0.37%. Ngo-Okthoba 15, amaseli e-CD7 CAR-T aphinde afakwa.

Ngomhlaka-3 Januwari (izinsuku ezingu-20 ngemuva kokufakwa kabusha), ukubhobozwa komnkantsha kwabonisa ukuphulukiswa okuphelele kokwakheka, kungekho maseli angakavuthwa atholakala yi-flow cytometry. Isimo sikaXiaohong sesizinzile kusukela lapho, futhi udluliselwe emnyangweni wokufakelwa ukuze alungiselele ukufakelwa kweseli le-hematopoietic stem cell.

UXiaohong wayengaphansi konyaka ubudala lapho egula futhi wabekezelela ukwelashwa ngemithi isikhathi esingaphezu konyaka. Ukuphumelela kokuhlangana nokufakelwa izicubu ngemuva kokwelashwa nge-CD7 CAR-T kuye kwanikeza isikhali esinamandla sokunqoba lesi sifo ngokuphelele.