Khansa ya m'magazi ya Lymphoblastic (T-ALL)-06

Wodwala wazaka ziwiri yemwe ali ndi T-ALL wachira atalandira chithandizo cha CAR-T atalandira mankhwala amphamvu a chemotherapy kwa nthawi zoposa khumi.

Xiaohong wazaka ziwiri wochokera ku Zhejiang adapezeka ndi khansa ya m'magazi chilimwe chatha. Pambuyo pa chithandizo cha chaka choposa chaka chimodzi, flow cytometry idazindikira kuti yabwereranso, zomwe zidapangitsa banjali kufunafuna chithandizo cha CAR-T immunotherapy ku BIOOCUS Medical Group.

Pa Ogasiti 9, 2020, Xiaohong adalowa m'chipatala cha ana chapafupi chifukwa cha "malungo a masiku atatu." Kuwunika kwa MICM ya m'mafupa kunapeza kuti ali ndi khansa ya m'magazi yotchedwa acute lymphoblastic leukemia (T-ALL). Pambuyo pa chemotherapy imodzi, mawonekedwe a m'mafupa adawonetsa kuchira kwathunthu, ndipo flow cytometry sinapeze maselo osakhwima. Chemotherapy yowonjezereka pambuyo pake pa maphunziro 11 idasunga kuchira kwathunthu kwa m'mafupa.

Pa Seputembala 3, 2021, kuphulika kwa mafupa pambuyo pake kunawonetsa kuchira kwathunthu mu mawonekedwe a thupi, koma flow cytometry inapeza 1.85% ya maselo osakhwima omwe anali ndi khansa. Pofuna chithandizo china, Xiaohong anagonekedwa kuchipatala chathu cha CGT pa Seputembala 24. Atalandira chithandizo, mawonekedwe a mafupa anali akadali omasuka kwathunthu, koma immunophenotyping inasonyeza 0.10% ya ma lymphocyte a T osakhwima omwe anali ndi khansa.

Poganizira za unyamata wa Xiaohong komanso kupitirira kwa matendawa ngakhale kuti adapatsidwa mankhwala amphamvu a chemotherapy kwa nthawi zoposa khumi, gulu lachipatala la mu wadi yachiwiri ya dipatimenti ya hematology linaganiza kuti Xiaohong akhoza kulembetsa mu mayeso azachipatala a CD7 CAR-T.

Pa Seputembala 30, 2021, maselo a m'magazi ozungulira adasonkhanitsidwa kuti azitha kupanga maselo a CAR-T. Pa Okutobala 10, Xiaohong adalandira mankhwala a FC regimen chemotherapy. Pa Okutobala 13, kubowola kwa mafupa kunawonetsa kuphulika kosakwana 5% mu mawonekedwe, ndipo flow cytometry inasonyeza kuti maselo a T osakhwima anali 0.37%. Pa Okutobala 15, maselo a CD7 CAR-T adabwezeretsedwanso.

Pa Januwale 3 (masiku 20 pambuyo pobwezeretsanso), kubowoledwa kwa mafupa kunawonetsa kuchira kwathunthu mu mawonekedwe ake, popanda maselo osakhwima omwe adapezeka ndi flow cytometry. Matenda a Xiaohong adakhazikika kuyambira pamenepo, ndipo adasamutsidwira ku dipatimenti yosinthira maselo kuti akonzekere kusinthira maselo oyambira a hematopoietic hematopoietic.

Xiaohong anali ndi chaka chimodzi asanakwanitse chaka chimodzi pamene anadwala ndipo analandira chithandizo cha mankhwala kwa chaka chimodzi. Kupambana kumeneku kunathandiza kwambiri poika munthu wina pambuyo pa chithandizo cha CD7 CAR-T kwapereka chida champhamvu chothetsera matendawa kwathunthu.