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Mlandu Wodziwika

Kufalitsa Large B-cell lymphoma (DLBCL)-04

Chithandizo cha CAR-T cha Myasthenia Gravis (MG)

Chithandizo cha Kachilombo ka Oncolytic: Chithandizo Chapamwamba cha Khansa

Mnyamata akuvutika ndi khansa ya m'magazi ya acute lymphoblastic

Kugonjetsa Lymphoma Yaikulu ya B-Cell ndi Bioocus Dual CAR-T Therapy

Kulimbana ndi Khansa ya Hepatocellular ndi Bioocus GPC3 CAR-T Therapy

$Yankho Lodabwitsa mu Refractory Multiple Myeloma Pambuyo pa Chithandizo cha Maselo a CAR-T$

Yankho Lodabwitsa mu Refractory Multiple Myeloma Pambuyo pa Chithandizo cha Maselo a CAR-T

Kupambana kwa Madhavan: Kugonjetsa Ubongo wa Glioma ndi Chithandizo cha Bioocus B7H3 CAR-T

Mnyamata wolimba mtima wochokera ku Russia akulimbana ndi neuroblastoma

Munthu wodzipereka wochokera ku India akulimbana ndi khansa ya m'mimba

Khansa ya m'magazi ya Lymphoblastic (T-ALL)-05

WodwalaWosadziwika

Jenda：Mwamuna

Zaka: Zaka 15

UfuluChitchaina

Kuzindikira matenda:Acute Lymphoblastic Leukemia (T-ALL)

Lumikizanani nafe

Kukhululukidwa kwa Wodwala wa T-ALL Wobwerera M'mbuyo ndi Khansa ya M'mitsempha Yapakati Pambuyo pa Chithandizo cha CAR-T

Nkhaniyi ikukhudza mnyamata wazaka 16 wochokera kumpoto chakum'mawa kwa China, yemwe ulendo wake wokhala ndi khansa ya m'magazi wakhala wodzaza ndi mavuto kuyambira pomwe adapezeka ndi matendawa chaka chatha.

Pa Novembala 8, 2020, Dawei (dzina lodziwika bwino) adapita kuchipatala chapafupi chifukwa cha kuuma kwa nkhope, ziphuphu, komanso pakamwa pokhota. Anapezeka ndi "acute lymphoblastic leukemia (mtundu wa T-cell)." Pambuyo pa maphunziro amodzi a chemotherapy, MRD (matenda ochepa otsalira) sanapezeke ndi khansa, kenako analandira chemotherapy yokhazikika. Panthawiyi, kuboola mafupa, kuboola lumbar, ndi jakisoni wamkati sizinawonetse vuto lililonse.

Pa Meyi 6, 2021, kuboola lumbar ndi jakisoni wamkati mwa fupa la msana kunachitika, ndipo kusanthula kwa madzi a m'mitsempha ya msana (CSF) kunatsimikizira "leukemia ya m'mitsempha yapakati." Izi zinatsatiridwa ndi njira ziwiri zochiritsira matenda a chemotherapy. Pa Juni 1, kuboola lumbar ndi kusanthula kwa CSF kunawonetsa maselo osakhwima. Kuboola lumbar kwina katatu kowonjezera ndi jakisoni wamkati kunaperekedwa, ndipo mayeso omaliza a CSF sanawonetse maselo otupa.

Pa Julayi 7, Dawei adataya masomphenya m'diso lake lamanja, zomwe zidachepetsa kuwona bwino. Atalandira chithandizo chamankhwala cha chemotherapy kamodzi kokha, maso ake amanja adabwerera mwakale.

Pa Ogasiti 5, maso ake a diso lamanja anawonongekanso, zomwe zinapangitsa kuti asamaone bwino, ndipo diso lake lamanzere linayamba kusaona bwino. Kuyambira pa Ogasiti 10 mpaka 13, adachitidwa chithandizo cha radiotherapy cha ubongo wonse ndi msana (TBI), chomwe chinabwezeretsa masomphenya m'diso lake lamanzere, koma diso lamanja linakhalabe losaona bwino. Pa Ogasiti 16, MRI scan ya ubongo inasonyeza kusintha pang'ono pakukhuthala kwa mitsempha ya optic yakumanja ndi chiasm, ndipo kuwonjezeka kunawonedwa. Palibe zizindikiro zachilendo kapena kuwonjezeka komwe kunapezeka mu ubongo wa parenchyma.

Pa nthawiyi, banjali linali litakonzekera kuikidwa m'mafupa, likungoyembekezera bedi m'chipinda choikamo. Mwatsoka, kufufuza kwachizolowezi asanaikidwe m'thupi kunavumbula mavuto omwe anapangitsa kuti kusakidwa kwa m'thupi kukhale kovuta.

Pa Ogasiti 30, kuboola mafupa kunachitika, zomwe zinasonyeza kuti MRD ya m'mafupa yokhala ndi ma T lymphocytes osakhwima omwe ali ndi 61.1%. Kuboola mafupa m'chiuno ndi jakisoni wamkati kunachitidwanso, zomwe zinasonyeza kuti CSF MRD yokhala ndi maselo 127 onse, omwe ma T lymphocytes osakhwima anali 35.4%, zomwe zikusonyeza kuti khansa ya m'magazi yabwereranso mwakale.

Pa Ogasiti 31, 2021, Dawei ndi banja lake anafika ku chipatala chathu cha CGT. Mayeso a magazi omwe adalandiridwa adawonetsa: WBC 132.91×10^9/L; kusiyana kwa magazi a m'mphepete mwa thupi (mawonekedwe): 76.0% blasts. Chithandizo cha chemotherapy choyambitsa matenda chinaperekedwa pa mlingo umodzi.

Pambuyo pofufuza chithandizo cha Dawei chomwe adalandira kale, zidawonekeratu kuti T-ALL yake inali yofooka/yobwerera m'mbuyo ndipo maselo a chotupa adalowa muubongo, zomwe zidakhudza mitsempha ya maso. Gulu lachipatala lidapeza kuti Dawei adakwaniritsa zofunikira kuti alembetsedwe mu mayeso azachipatala a CD7 CAR-T.

Pa Seputembala 18, kafukufuku wina adachitika: kusiyana kwa magazi m'magazi (mawonekedwe) kunawonetsa kuphulika kwa 11.0%. Ma lymphocyte am'magazi ozungulira adasonkhanitsidwa kuti apeze maselo a CD7 CAR-T tsiku lomwelo, ndipo njirayi idayenda bwino. Pambuyo potenga, chemotherapy idaperekedwa kuti ikonzekere chithandizo cha chitetezo cha mthupi cha maselo a CD7 CAR-T.

Pa nthawi ya chemotherapy, maselo a chotupa anachulukana mofulumira. Pa Okutobala 6, kusiyana kwa magazi m'magazi (morphology) kunawonetsa kuphulika kwa 54.0%, ndipo njira ya chemotherapy inasinthidwa kuti ichepetse kuchuluka kwa chotupa. Pa Okutobala 8, kusanthula kwa mawonekedwe a maselo a m'mafupa kunawonetsa kuphulika kwa 30.50%; MRD inasonyeza kuti 17.66% ya maselo anali ma T lymphocytes osakhwima.

Pa Okutobala 9, maselo a CD7 CAR-T anabwezeretsedwa. Pambuyo pobwezeretsanso, wodwalayo adamva kutentha thupi komanso kupweteka m'kamwa. Ngakhale kuti chithandizo chowonjezera cha mankhwala oletsa matenda sichinathetsedwe bwino, ngakhale kuti kupweteka m'kamwa kunachepa pang'onopang'ono.

Pa tsiku la 11 pambuyo pobwezeretsanso magazi, kuphulika kwa magazi m'mitsempha kunakwera kufika pa 54%; pa tsiku la 12, mayeso a magazi adawonetsa kuti maselo oyera amagazi akukwera kufika pa 16 × 10 ^ 9 / L. Pa tsiku la 14 pambuyo pobwezeretsanso magazi, wodwalayo adakhala ndi CRS yayikulu, kuphatikizapo kuwonongeka kwa mtima, kulephera kugwira ntchito bwino kwa chiwindi ndi impso, kuchepa kwa magazi m'thupi, kuchepa kwa magazi m'mimba, komanso kukomoka. Mankhwala amphamvu owonetsa zizindikiro komanso othandizira, pamodzi ndi kusinthana kwa plasma, pang'onopang'ono adawongolera magwiridwe antchito a ziwalo zomwe zakhudzidwa, ndikukhazikitsa zizindikiro zofunika kwambiri za wodwalayo.

Pa Okutobala 27, wodwalayo anali ndi mphamvu ya minofu ya 0-grade m'miyendo yonse iwiri ya m'munsi. Pa Okutobala 29 (masiku 21 pambuyo pobwezeretsanso), mayeso a MRD a m'mafupa adapezeka kuti alibe.

Atachira kwathunthu, Dawei analimbitsa ntchito ya miyendo yake ya m'munsi mothandizidwa ndi anamwino ndi abale ake, pang'onopang'ono anabwezeretsa mphamvu ya minofu kufika pa giredi 5. Pa Novembala 22, anasamutsidwira ku dipatimenti yosamalira ziwalo kuti akonzekere kusamalidwa maselo oyambira a magazi otchedwa allogeneic hematopoietic.

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Kufalitsa Large B-cell lymphoma (DLBCL)-04

Chithandizo cha CAR-T cha Myasthenia Gravis (MG)

Chithandizo cha Kachilombo ka Oncolytic: Chithandizo Chapamwamba cha Khansa

Mnyamata akuvutika ndi khansa ya m'magazi ya acute lymphoblastic

Kugonjetsa Lymphoma Yaikulu ya B-Cell ndi Bioocus Dual CAR-T Therapy

Kulimbana ndi Khansa ya Hepatocellular ndi Bioocus GPC3 CAR-T Therapy

Yankho Lodabwitsa mu Refractory Multiple Myeloma Pambuyo pa Chithandizo cha Maselo a CAR-T

Kupambana kwa Madhavan: Kugonjetsa Ubongo wa Glioma ndi Chithandizo cha Bioocus B7H3 CAR-T

Mnyamata wolimba mtima wochokera ku Russia akulimbana ndi neuroblastoma

Munthu wodzipereka wochokera ku India akulimbana ndi khansa ya m'mimba

Khansa ya m'magazi ya Lymphoblastic (T-ALL)-05

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Khansa ya m'magazi ya Lymphoblastic (T-ALL)-03

Khansa ya m'magazi ya Lymphoblastic (T-ALL)-10

Khansa ya m'magazi ya Lymphoblastic (T-ALL)-06

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