Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)-06

Murwere wevana ane makore maviri ekuberekwa ane chirwere cheT-ALL anowana zororo mushure mekurapwa neCAR-T mushure mekupihwa chemotherapy yakasimba kweanopfuura gumi.

Xiaohong ane makore maviri ekuberekwa wekuZhejiang akaonekwa aine leukemia zhizha rapfuura. Mushure mekurapwa kwegore rinodarika, flow cytometry yakaona kuti chirwere ichi chadzoka, zvikaita kuti mhuri itsvage CAR-T immunotherapy kuBIOOCUS Medical Group.

Musi wa9 Nyamavhuvhu, 2020, Xiaohong akapinda muchipatara chevana chemunharaunda nekuda kwe "fivha yemazuva matatu." Kuongororwa kweMICM yemapfupa kwakaratidza kuti ane chirwere cheacute lymphoblastic leukemia (T-ALL). Mushure meimwe nzira yechemotherapy, chimiro chemapfupa emapfupa chakaratidza kurerukirwa kwakakwana, uye flow cytometry haina kuona masero asina kukura. Kemotherapy yakatevera pamusoro pemakosi gumi nerimwe yakachengetedza kurerukirwa kwakakwana kwemapfupa emapfupa.

Musi wa3 Gunyana, 2021, kupunzika kwemapfupa kwakaratidza kurerukirwa kwakazara muchimiro chemasero, asi flow cytometry yakaratidza 1.85% masero asina kukura zvakanaka. Achitsvaga kumwe kurapwa, Xiaohong akagamuchirwa kuCGT centre yedu musi wa24 Gunyana. Paakapinda muchipatara, chimiro chemapfupa asina kukura chakanga chichiri kurerukirwa zvakakwana, asi immunophenotyping yakaratidza 0.10% malignant immature T lymphocytes.

Tichifunga nezvezera raXiaohong uye kuramba aripo kwechirwere ichi pasinei nekupiwa mishonga inouraya kenza kwenguva inopfuura gumi, timu yezvekurapa muwadhi yechipiri yedhipatimendi rekuongorora ropa yakasarudza kuti Xiaohong anyorese muongororo yekiriniki yeCD7 CAR-T.

Musi wa30 Gunyana, 2021, masero eropa akaunganidzwa kuti agadziriswe masero eCAR-T. Musi wa10 Gumiguru, Xiaohong akapihwa chemotherapy yeFC. Musi wa13 Gumiguru, kubhoorwa kwebhonzo remumaro kwakaratidza kuputika kuri pasi pe5% muchimiro, uye flow cytometry yakaratidza 0.37% masero eT asina kukura ane malignant. Musi wa15 Gumiguru, masero eCD7 CAR-T akadzorerwa.

Musi wa3 Ndira (mazuva makumi maviri mushure mekuiswazve muropa), kukuvara kwemapfupa kwakaratidza kugadzikana kwakakwana muchimiro chemuviri, pasina masero asina kukura akaonekwa ne flow cytometry. Mamiriro aXiaohong akagadzikana kubva ipapo, uye akatamisirwa kudhipatimendi rekuisirwa masero kuti agadzirire kuisirwa masero eropa anokonzerwa ne allogeneic hematopoietic.

Xiaohong akanga asati asvitsa gore rimwe chete paakarwara uye akatsungirira kurapwa kweanopfuura gore. Kubudirira kwekubatanidza murwere nekubvisa chirwere ichi mushure mekurapwa neCD7 CAR-T kwakamupa chombo chakasimba chekukunda chirwere ichi zvachose.