Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)-09

Mudzidzi wepayunivhesiti anonzi Mengmeng anobva kuYanjiao, Guizhou, akapihwa kurapwa kuBIOOCUS Medical Group.

Mengmeng, mukadzi ane makore makumi maviri nerimwe ekuberekwa, akaonekwa kukiriniki yedu yekurerutsira varwere musi wa22 Chikumi 2021, aine kuneta kunogara kwenguva refu. Kuongororwa kweropa kwakaratidza kuti WBC 479×10^9/L. Kuongororwazve kwemapfupa kwakaratidza kuti acute lymphoblastic leukemia (T-cell subtype). Akaitwa chemotherapy kaviri, asi leukemia haina kupindura, MRD (chirwere chidiki chekugara) pa56.01%, uye aivewo nechirwere che central nervous system leukemia.

Musi wa13 Nyamavhuvhu, ma lymphocytes e autologous akatorwa uye chemotherapy yakapihwa. Musi wa30 Nyamavhuvhu, Mengmeng akapihwa CD7 CAR-T cell infusion. Vhiki mbiri mushure mekupihwa, kuongororwa kwemapfupa kwakaratidza kuregererwa kwakakwana, MRD negativity, uye kudzora central nervous system leukemia. Akasangana ne grade 1 cytokine release syndrome (CRS) reaction pasina central nervous system reaction.