ʻO ka maʻi leukemia lymphoblastic koʻikoʻi (T-ALL)-06

Ua loaʻa i kahi keiki maʻi 2 makahiki me T-ALL ke kala ʻia ma hope o ka lāʻau lapaʻau CAR-T ma hope o ʻoi aku ma mua o ʻumi mau puni o ka chemotherapy ikaika.

Ua ʻike ʻia ʻo Xiaohong, ʻelua makahiki, mai Zhejiang mai, ua loaʻa iā ia ka maʻi leukemia i ke kauwela i hala. Ma hope o hoʻokahi makahiki o ka mālama ʻana, ua ʻike ʻia kahi hoʻi hou ʻana o ka maʻi, a ua alakaʻi ʻia ka ʻohana e ʻimi i ka CAR-T immunotherapy ma BIOOCUS Medical Group.

Ma ʻAukake 9, 2020, ua hoʻokomo ʻia ʻo Xiaohong i kahi haukapila o nā keiki kūloko ma muli o ka "fiva ʻekolu lā." Ua ʻike ʻia ka hoʻokolokolo ʻana o ka iwi MICM i ka leukemia lymphoblastic acute (T-ALL). Ma hope o hoʻokahi papa o ka chemotherapy, ua hōʻike ke ʻano o ka iwi iwi i ke kala piha ʻana, a ʻaʻole i ʻike ka cytometry kahe i nā cell malignant immature. ʻO ka chemotherapy ikaika ma hope ma luna o 11 mau papa i mālama i ke kala piha ʻana o ka iwi iwi.

Ma Kepakemapa 3, 2021, ua hōʻike ʻia kahi puncture iwi iwi ma hope o ke kala piha ʻana i ke ʻano, akā ua hōʻike ka cytometry kahe i ka 1.85% o nā cell immature malignant. I ka ʻimi ʻana i ka lāʻau lapaʻau hou aku, ua hoʻokomo ʻia ʻo Xiaohong i kā mākou kikowaena CGT ma Kepakemapa 24. I ka wā i komo ai, ua kala piha ʻia ke ʻano o ka iwi iwi, akā ua hōʻike ka immunophenotyping i ka 0.10% malignant immature T lymphocytes.

Ke noʻonoʻo nei i ka wā ʻōpiopio o Xiaohong a me ke kūpaʻa o ka maʻi ʻoiai ua ʻoi aku ma mua o ʻumi mau pōʻai o ka chemotherapy koʻikoʻi, ua hoʻoholo ka hui lapaʻau ma ka lua o ka keʻena hematology e hiki iā Xiaohong ke kākau inoa i ka hoʻokolohua lapaʻau CD7 CAR-T.

Ma Kepakemapa 30, 2021, ua hōʻiliʻili ʻia nā hunaola koko peripheral no ka moʻomeheu cell CAR-T. Ma ʻOkakopa 10, ua loaʻa iā Xiaohong ka chemotherapy regimen FC. Ma ʻOkakopa 13, ua hōʻike kahi puncture bone ma lalo o 5% blasts i ke ʻano, a ua hōʻike ka flow cytometry i 0.37% malignant immature T cells. Ma ʻOkakopa 15, ua hoʻokomo hou ʻia nā hunaola CD7 CAR-T.

Ma Ianuali 3 (20 mau lā ma hope o ka hoʻokomo hou ʻana), ua hōʻike kahi ʻoki ʻana o ka iwi iwi i ke kala piha ʻana i ke ʻano, me ka ʻole o nā pūnaewele ʻōpiopio ʻino i ʻike ʻia e ka cytometry kahe. Ua paʻa ke kūlana o Xiaohong mai ia manawa, a ua hoʻoneʻe ʻia ʻo ia i ka ʻoihana hoʻoili e hoʻomākaukau no kahi hoʻoili cell kumu hematopoietic allogeneic.

ʻAʻole i piha ʻo Xiaohong i hoʻokahi makahiki i ka wā i maʻi ai ʻo ia a ua hoʻomanawanui i ka mālama ʻana i ka lāʻau lapaʻau no hoʻokahi makahiki. ʻO ka hoʻopili kūleʻa ʻana i ka hoʻoili ʻana ma hope o ka lāʻau lapaʻau CD7 CAR-T ua hāʻawi mai i kahi mea kaua ikaika e lanakila loa ai i ka maʻi.