ʻO ka maʻi leukemia lymphoblastic koʻikoʻi (T-ALL)-10

Ua hana ʻia kekahi CAR-T i kekahi keikikāne he 13 makahiki i kapa ʻia ʻo Yangyang mai Panzhihua, Panalāʻau ʻo Sichuan, a ukali ʻia e ka hoʻoili ʻana o ka lāʻau bridging.

Ua hōʻike mua ʻo Yangyang me nā "palapala i hoʻopuehu ʻia ma ke kino holoʻokoʻa i hele pū ʻia me ka luhi" ma ʻApelila 12, 2021. Ua ʻike ʻia ʻo ia he leukemia lymphoblastic acute (T-cell subtype) me ke kahe koko intracranial a me ka maʻi māmā i hōʻoia ʻia e ka hoʻokolokolo ʻana o ka iwi marrow MICM ma kahi haukapila nui ma Chongqing. Ua hana ʻo ia i 3 mau pōʻaiapuni o ka chemotherapy ma kahi haukapila ʻē aʻe, akā ʻaʻole i pane mai ka iwi marrow. I ka hoʻomaka ʻana o Iune, ua loaʻa iā ia ka nāwaliwali ma nā lālā haʻahaʻa ʻelua a ʻaʻole hiki ke hele.

Ma Iulai 1, 2021, ua hoʻokomo ʻia ʻo Yangyang i kā mākou Hematology Department Ward 2. Ua kākau inoa ʻo ia i ka hoʻokolohua lapaʻau CD7 CAR-T ma Iulai 8 a ua loaʻa iā ia ka autologous CD7 CAR-T cell infusion ma Iulai 26 no ka immunotherapy. He ʻumikumamāono lā ma hope o ka infusion, ua hōʻike ke ʻano o ka iwi iwi i ka hoʻomaha ʻana, a ua hōʻike ka cytometry kahe i ka 0.07% suspicious malignant immature T lymphoblasts. Ma hope o ka hoʻōla kino, ua loaʻa iā ia ka hiki ke hele kūʻokoʻa. I ka lā 31 ma hope o ka infusion, ua hoʻopau piha ʻia kona iwi iwi.

I kēia manawa, ua hoʻoneʻe ʻia ʻo Yangyang i ka Ward 6 o ka Bone Marrow Transplantation Department no ka mālama hou ʻana. Ua ʻōlelo ʻo Kauka Hai mai ka Ward 6 ua hana pū ʻo Yangyang a me ka manaʻolana i kāna mālama ʻana. Ua hana ʻia ʻo ia i ka allogeneic hematopoietic stem cell transplantation (mai kona makuakāne mai) ma Kepakemapa 28. Ua mahalo nui ʻia nā kūlana i hana ʻia e nā hoa hana o ka Hematology Department no kāna bridging transplantation.

Ma mua o ke kākau inoa ʻana i ka hoʻokolohua lapaʻau CD7 CAR-T, ua hōʻike ʻia kēia mau maʻi me nā hōʻailona like ʻole e like me ka hoʻihoʻi ʻana ma hope o ke kāpili ʻana, ka hōʻike pālua T/myeloid, ka leukemia T-cell acute refractory/resistant, ka leukemia ʻōnaehana nerve waena, ka hemorrhage intracranial, a me ka maʻi māmā. Ma hope o ka loiloi a me ka mālama ʻana me ka lāʻau lapaʻau CD7 CAR-T, ua hoʻokō lākou a pau i ke kala piha ʻana, e hoʻokō ana i nā hopena i manaʻo ʻia.

Ua ʻimi ikaika kā mākou kikowaena CGT i ke kahua o ka lāʻau lapaʻau CAR-T a ua hōʻiliʻili i ka ʻike nui i ka mālama ʻana i ka CRS. No ka hapa nui o ka poʻe i komo, ʻo ka hopena ʻino loa, ʻo ia ke kuni kiʻekiʻe. "Hiki iaʻu ke hoʻopau piha, no laila ʻaʻohe mea ke kuni! Makemake au e ʻike ka poʻe hou aku e hiki iā BIOOCUS ke hana iā CAR-T!" wahi a Yangyang mai Fujian i ka wā i hoʻokuʻu ʻia ai.