Ciwon sankarar lymphoblastic mai tsanani (T-ALL)-10

An yi wa wani yaro mai shekaru 13 mai suna Yangyang daga Panzhihua, Lardin Sichuan dashen CAR-T sannan aka yi masa dashen gada.

Da farko Yangyang ya fara bayyana da "ƙuraje a jiki tare da gajiya" a ranar 12 ga Afrilu, 2021. An gano yana da cutar sankarar lymphoblastic mai tsanani (nau'in ƙwayoyin T) tare da zubar jini a cikin kwakwalwa da kuma kamuwa da cutar huhu da aka tabbatar ta hanyar binciken MICM a wani babban asibiti a Chongqing. Ya yi zagaye uku na chemotherapy a wani asibiti, amma ƙashin ƙashi bai yi aiki ba. A farkon watan Yuni, ya sami rauni a ƙananan gaɓoɓi biyu kuma bai iya tafiya ba.

A ranar 1 ga Yuli, 2021, an kwantar da Yangyang a sashen kula da cututtukan jini na sashenmu na 2. Ya shiga gwajin asibiti na CD7 CAR-T a ranar 8 ga Yuli kuma an yi masa allurar CD7 CAR-T ta kansa a ranar 26 ga Yuli don maganin rigakafi. Kwanaki 16 bayan allurar, yanayin ƙashin ƙashi ya nuna sassauci, kuma kwararar cytometry ta nuna kashi 0.07% na ƙwayoyin T lymphoblasts marasa ƙarfi. Bayan jiyya ta jiki, ya sake samun ikon tafiya da kansa. A rana ta 31 bayan allurar, ƙashin ƙashinsa ya sami cikakkiyar sassauci.

A halin yanzu, an mayar da Yangyang zuwa Ward 6 na Sashen Dashen Ƙashi don ƙarin magani. Dr. Hai daga Ward 6 ya bayyana cewa Yangyang ya kasance mai haɗin kai da kyakkyawan fata a duk lokacin da yake jinya. An yi masa dashen ƙwayoyin halittar jini na allogeneic (daga mahaifinsa) a ranar 28 ga Satumba. An yaba da yanayin da abokan aikin Sashen Kula da Cututtuka suka haifar don dashensa.

Waɗannan marasa lafiya, kafin a yi musu rajista a gwajin asibiti na CD7 CAR-T, sun gabatar da alamu daban-daban kamar sake dawowa bayan dashen, bayyanar T/myeloid mai kama da juna, cutar sankarar T-cell mai tsanani mai jurewa/mai jurewa, cutar sankarar jijiyoyi ta tsakiya, zubar jini a cikin kwakwalwa, da kuma kamuwa da cutar huhu. Bayan tantancewa da magani da CD7 CAR-T, duk sun sami cikakkiyar sassauci, inda suka cimma sakamakon da ake tsammani.

Cibiyarmu ta CGT ta yi bincike sosai a fannin maganin CAR-T kuma ta tara ƙwarewa mai yawa wajen kula da CRS. Ga yawancin mahalarta, mafi munin illa ita ce zazzabi mai zafi. "Zan iya samun cikakkiyar sassauci, don haka zazzabin ba komai ba ne! Ina so mutane da yawa su san cewa BIOOCUS zai iya yin CAR-T!" in ji Yangyang daga Fujian bayan an sallame shi daga asibiti.