I-Acute Lymphoblastic Leukemia (T-ALL)-10

Inkwenkwe eneminyaka eli-13 ubudala egama linguYangyang yasePanzhihua, kwiPhondo laseSichuan, iye yafakwa kwi-CAR-T yaza yafakelwa i-bridging transplant.

UYangyang waqala waba "neemivumbo ezisasazekileyo emzimbeni wonke ezihamba nokudinwa" nge-12 ka-Epreli 2021. Wafunyaniswa ukuba une-acute lymphoblastic leukemia (i-T-cell subtype) kunye nokopha kwegazi ngaphakathi kwentloko kunye nosulelo lwemiphunga oluqinisekiswe luvavanyo lwe-bone marrow MICM kwisibhedlele esikhulu eChongqing. Wenziwa imijikelo emithathu ye-chemotherapy kwesinye isibhedlele, kodwa i-bone marrow ayizange iphendule. Ekuqaleni kukaJuni, waba nobuthathaka kwimilenze yomibini esezantsi kwaye wayengakwazi ukuhamba.

Ngomhla woku-1 kuJulayi 2021, uYangyang wangeniswa kwiCandelo lethu leHematology Ward 2. Wabhalisa kwisilingo seklinikhi seCD7 CAR-T ngomhla wesi-8 kuJulayi waza wafumana i-autologous CD7 CAR-T cell infusion ngomhla wama-26 kuJulayi ukuze afumane i-immunotherapy. Emva kweentsuku ezilishumi elinesithandathu emva kokufakwa, i-bone marrow morphology yabonisa ukuxolelwa, kwaye i-flow cytometry yabonisa i-0.07% ye-malignant immature T lymphoblasts erhanelekayo. Emva konyango lomzimba, wakwazi ukuhamba ngokuzimeleyo. Ngomhla wama-31 emva kokufakwa, i-bone marrow yakhe yafumana ukuxolelwa ngokupheleleyo.

Okwangoku, uYangyang udluliselwe kwiWadi 6 yeSebe le-Bone Marrow Transplantation ukuze afumane unyango olongezelelekileyo. UGqr. Hai waseWadi 6 uthe uYangyang ebesebenzisana ngokukhutheleyo kwaye enethemba kulo lonke unyango lwakhe. Wenziwe utyando lwe-allogeneic hematopoietic stem cell (oluvela kuyise) nge-28 kaSeptemba. Iimeko ezidalwe ngoogxa bakhe kwiSebe le-Hematology zotyando lwakhe lwe-bridging zaxatyiswa kakhulu.

Ezi zigulana, ngaphambi kokubhaliswa kuvavanyo lweklinikhi lwe-CD7 CAR-T, zibonakalise iimpawu ezahlukeneyo ezifana nokubuyela umva emva kokufakelwa, ukubonakaliswa kwe-T/myeloid dual, i-refractory/resistant acute T-cell leukemia, i-central nervous system leukemia, ukopha kwegazi ngaphakathi kwentloko, kunye nosulelo lwemiphunga. Emva kovavanyo kunye nonyango nge-CD7 CAR-T therapy, zonke zifumene uxolelo olupheleleyo, zihlangabezana neziphumo ebezilindelwe.

Iziko lethu le-CGT liye lahlola ngokukhutheleyo kwicandelo lonyango lwe-CAR-T kwaye laqokelela amava atyebileyo ekulawuleni i-CRS. Kwabaninzi abathathi-nxaxheba, eyona miphumo mibi kakhulu yayiyimfiva ephezulu. "Ndingafumana ukuphumla ngokupheleleyo, ngoko ke umfiva awunto yanto! Ndifuna abantu abaninzi bazi ukuba i-BIOOCUS inokuyenza i-CAR-T!" utshilo uYangyang waseFujian emva kokukhululwa kwakhe.