Kab mob qog ntshav Lymphoblastic mob hnyav (T-ALL)-10

Ib tug tub hluas hnub nyoog 13 xyoos hu ua Yangyang los ntawm Panzhihua, xeev Sichuan, tau ua CAR-T tom qab ntawd hloov hlwb.

Thaum xub thawj Yangyang tau mob "mob thoob plaws lub cev nrog rau qaug zog" rau lub Plaub Hlis 12, 2021. Nws tau kuaj pom tias muaj mob leukemia lymphoblastic (T-cell subtype) nrog rau kev los ntshav hauv lub hlwb thiab mob ntsws uas tau lees paub los ntawm kev kuaj mob pob txha MICM ntawm lub tsev kho mob loj hauv Chongqing. Nws tau phais mob chemotherapy 3 zaug ntawm lwm lub tsev kho mob, tab sis pob txha tsis teb. Thaum pib Lub Rau Hli, nws tau pib qaug zog hauv ob txhais ceg thiab tsis tuaj yeem taug kev.

Thaum Lub Xya Hli 1, 2021, Yangyang tau raug xa mus rau peb Chav Saib Xyuas Kab Mob Ntshav 2. Nws tau koom nrog kev sim tshuaj CD7 CAR-T thaum Lub Xya Hli 8 thiab tau txais kev txhaj tshuaj CD7 CAR-T cell rau lub Xya Hli 26 rau kev kho mob tiv thaiv kab mob. Kaum rau hnub tom qab txhaj tshuaj, cov qauv ntawm cov pob txha tau zoo lawm, thiab cov ntaub ntawv qhia tias muaj 0.07% ntawm cov T lymphoblasts tsis zoo uas tsis tau loj hlob. Tom qab kev kho mob lub cev, nws tau rov qab taug kev tau ywj pheej. Thaum txog hnub 31 tom qab txhaj tshuaj, nws cov pob txha tau zoo tag nrho.

Tam sim no, Yangyang tau raug xa mus rau Ward 6 ntawm Chav Hloov Pob Txha kom tau txais kev kho mob ntxiv. Dr. Hai los ntawm Ward 6 tau hais tias Yangyang tau koom tes thiab muaj kev cia siab thoob plaws nws txoj kev kho mob. Nws tau txais kev hloov hlwb allogeneic hematopoietic stem cell (los ntawm nws txiv) rau lub Cuaj Hlis 28. Cov xwm txheej uas tsim los ntawm cov npoj yaig ntawm Chav Hematology rau nws txoj kev hloov hlwb tau txais kev txaus siab heev.

Cov neeg mob no, ua ntej lawv koom nrog kev sim tshuaj CD7 CAR-T, tau muaj ntau yam tsos mob xws li rov qab mob tom qab hloov hlwb, T/myeloid dual expression, refractory/resistant acute T-cell leukemia, central nervous system leukemia, intracranial hemorrhage, thiab mob ntsws. Tom qab kev ntsuam xyuas thiab kev kho mob nrog CD7 CAR-T therapy, txhua tus tau txais kev zam txim tag nrho, ua tau raws li qhov xav tau.

Peb lub chaw CGT tau tshawb nrhiav txog kev kho mob CAR-T thiab tau txais kev paub ntau yam hauv kev tswj hwm CRS. Rau feem ntau cov neeg koom nrog, qhov teeb meem loj tshaj plaws yog kub taub hau siab. "Kuv tuaj yeem ua tiav kev zam txim tag nrho, yog li qhov kub taub hau tsis muaj dab tsi! Kuv xav kom ntau tus neeg paub tias BIOOCUS tuaj yeem ua CAR-T!" Yangyang los ntawm Fujian hais thaum tawm hauv tsev kho mob.