Leukemia ikabije ya Lymphoblastic (T-ALL)-10

Umwana w'umuhungu w'imyaka 13 witwa Yangyang wo muri Panzhihua, mu Ntara ya Sichuan, yakorewe CAR-T hanyuma aterwa uruziga.

Yangyang yatangiye kugaragaraho "ibisebe bivanze n'umunaniro" ku ya 12 Mata 2021. Yasuzumwe indwara ya kanseri y'imitsi yo mu bwonko (T-cell leukemia) iterwa no kuva amaraso mu bwonko no kwandura ibihaha byemejwe n'isuzuma rya MICM mu igufwa mu bitaro binini byo muri Chongqing. Yakorewe imiti igabanya ubukana inshuro 3 mu bindi bitaro, ariko igufwa ntiryakira. Mu ntangiriro za Kamena, yagize intege nke mu maguru yombi yo hasi kandi ntiyashoboraga kugenda.

Ku ya 1 Nyakanga 2021, Yangyang yakiriwe mu ishami ryacu ry’ubuvuzi bw’amaraso mu cyumba cya 2 cy’ishami ryacu ryita ku ndwara z’amaraso. Yinjiye mu igeragezwa rya CD7 CAR-T ku ya 8 Nyakanga, ahabwa inshinge za CD7 CAR-T ku ya 26 Nyakanga kugira ngo ahabwe ubuvuzi bw’umubiri. Nyuma y’iminsi 16, imiterere y’umusemburo w’amagufwa yagaragaje ko yakize, kandi flow cytometry yagaragaje ko 0.07% by’uturemangingo twa T tutarakura twakekwaho kuba tumeze nabi. Nyuma yo kuvurwa no gukora imyitozo ngororamubiri, yongeye kugira ubushobozi bwo kugenda wenyine. Ku munsi wa 31 nyuma yo guterwa, umusemburo w’amagufwa ye wakize burundu.

Kuri ubu, Yangyang yimuriwe mu cyumba cya 6 cy’ishami rishinzwe gutera amagufwa kugira ngo akomeze kuvurwa. Dr. Hai wo mu cyumba cya 6 yavuze ko Yangyang yakoranye n’abandi kandi afite icyizere mu gihe cyose yavurwaga. Yakorewe intera y’uturemangingo tw’amaraso ya allogeneic (yakuwe kuri se) ku ya 28 Nzeri. Uburyo abakozi bo mu ishami rishinzwe gutera amagufwa bashyizeho kugira ngo atere amagufwa ye bwashimwe cyane.

Aba barwayi, mbere yo kwiyandikisha mu igerageza rya CD7 CAR-T, bagaragaje ibimenyetso bitandukanye nko gusubira inyuma nyuma yo guterwa, T/myeloid dual expression, acute T-cell leukemia, leukemia y’imitsi yo mu mutwe, kuva amaraso mu mutwe, no kwandura ibihaha. Nyuma yo gusuzuma no kuvurwa hakoreshejwe uburyo bwa CD7 CAR-T, bose bagaragaje koroherwa burundu, bahura n’ibyari byitezwe.

Ikigo cyacu cya CGT cyakoze ubushakashatsi ku bijyanye n'ubuvuzi bwa CAR-T kandi cyakusanyije ubunararibonye bwinshi mu kuvura CRS. Ku bitabiriye benshi, ingaruka mbi zikomeye cyane ni umuriro mwinshi. Yangyang wo muri Fujian yagize ati: "Nshobora kugabanya burundu umuriro, bityo umuriro ntacyo uvuze! Ndashaka ko abantu benshi bamenya ko BIOOCUS ishobora gukora CAR-T!"